磷酸化周期素依赖性激酶6抗体

英文名称    phospho-CDK6 (Tyr13)    

中文名称    磷酸化周期素依赖性激酶6抗体    

别    名    CDK6 (phospho-Tyr13); CDK 6; CDK6; Cell division protein kinase 6; Crk 2; Crk2; Cyclin dependent kinase 6 ; MGC59692; p40; PLSTIRE; Serine/threonine-protein kinase PLSTIRE; STQTL11;CDK6_HUMAN.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  免疫学  信号转导  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化周期素依赖性激酶6抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human CDK6 around the phosphorylation site of Tyr13    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化周期素依赖性激酶6抗体产品介绍    background:

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors.

Function:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.    

磷酸化周期素依赖性激酶6抗体

hz-9804R C2orf24  2号染色体开放阅读框24抗体

hz-9805R C2orf18/ANT2BP  2号染色体开放阅读框18抗体

hz-9806R APR3/C2orf28  凋亡相关蛋白3抗体

hz-9807R ECRG4/C2orf40  食道癌相关基因4蛋白抗体

hz-9808R C2ORF25  2号染色体开放阅读框25抗体

hz-9809R C2orf60  2号染色体开放阅读框抗体

hz-9810R C2orf68  2号染色体开放阅读框68抗体

hz-9811R C2ORF47  2号染色体开放阅读框47抗体

hz-9812R TCF9/GCF  转录因子9抗体

hz-9813R EGFR5/CLEC14A  表皮生长因子受体5抗体

hz-9814R C2orf44  2号染色体开放阅读框44抗体

hz-9815R C2orf42  2号染色体开放阅读框42抗体

hz-9816R C2orf43  2号染色体开放阅读框43抗体

hz-9817R C2orf55  2号染色体开放阅读框55抗体

hz-9818R C2orf57  2号染色体开放阅读框57抗体

hz-9819R C2orf69  2号染色体开放阅读框69抗体

hz-1649R phospho-APP/ABPP(Tyr757)  磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体

hz-9820R C2orf89  2号染色体开放阅读框89抗体

hz-9821R C2orf29  2号染色体开放阅读框29抗体

hz-9822R C3orf24  3号染色体开放阅读框24抗体

hz-9823R AAT1/C3orf15  3号染色体开放阅读框15抗体

hz-9824R C3orf17  3号染色体开放阅读框17抗体

hz-3028R phospho-APP/ABPP(Thr668)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9825R C3orf18  3号染色体开放阅读框18抗体

hz-9826R C3orf21/XXYLT1  3号染色体开放阅读框21抗体

hz-5167R phospho-APP/ABPP (Thr743)  磷酸化APP淀粉样肽前体蛋白抗体

hz-5168R phospho-APP/ABPP (Ser730)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9827R C3orf23  3号染色体开放阅读框23抗体

hz-9828R C3orf33  3号染色体开放阅读框33抗体

hz-5186R phospho-APP/ABPP(Thr743)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9829R C3orf37  3号染色体开放阅读框37抗体

hz-9830R C3orf39  3号染色体开放阅读框39抗体