磷酸化蛋白精氨酸N甲基4抗体

英文名称    phospho-CARM1(Ser228)    

中文名称    磷酸化蛋白精氨酸N甲基4抗体    

别    名    CARM1_HUMAN; Coactivator associated arginine methyltransferase 1; Coactivator-associated arginine methyltransferase 1; Histone arginine methyltransferase CARM 1; Histone arginine methyltransferase CARM1; Histone-arginine methyltransferase CARM1; PRMT 4; Protein arginine methyltransferase; Protein arginine N methyltransferase 4; Protein arginine N-methyltransferase 4.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  免疫学  染色质和核信号  信号转导  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500磷酸化蛋白精氨酸N甲基4抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    66kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human CARM1 around the phosphorylation site of Ser228    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化蛋白精氨酸N甲基4抗体产品介绍    background:

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C.

Function:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.     

磷酸化蛋白精氨酸N甲基4抗体

hz-9771R C10orf88  10号染色体开放阅读框88抗体

hz-9772R C10orf93  10号染色体开放阅读框93抗体

hz-9773R C10orf63/Enkurin  10号染色体开放阅读框63抗体

hz-9774R C10orf132/GOLGA7B  10号染色体开放阅读框132抗体

hz-9775R C10orf30/BEND7  10号染色体开放阅读框30抗体

hz-9776R C10orf140  10号染色体开放阅读框140抗体

hz-9777R C1orf125  1号染色体开放阅读框125抗体

hz-9778R C1orf129  1号染色体开放阅读框129抗体

hz-9779R C1orf159  1号染色体开放阅读框159抗体

hz-9780R C1orf163  1号染色体开放阅读框163抗体

hz-9781R C1orf172  1号染色体开放阅读框172抗体

hz-9782R C1orf2/COTE1  1号染色体开放阅读框2抗体

hz-9783R C1orf19/SEN15  1号染色体开放阅读框19抗体

hz-9784R C1orf25  1号染色体开放阅读框25抗体

hz-9785R C1orf31  1号染色体开放阅读框31抗体

hz-9786R C1orf51  1号染色体开放阅读框51抗体

hz-9787R C1orf52  1号染色体开放阅读框52抗体

hz-9788R C1orf67/DNAH14  1号染色体开放阅读框67抗体

hz-9789R C1orf83  1号染色体开放阅读框83抗体

hz-9790R AFAP/AFAP-110  微丝相关蛋白1抗体

hz-9791R C1ORF111  1号染色体开放阅读框111抗体

hz-9792R C1ORF74  1号染色体开放阅读框74抗体

hz-9793R C1QL2/C1QTNF10  补体C1q和肿瘤坏死因子相关蛋白10

hz-9794R C1orf93  1号染色体开放阅读框93抗体

hz-9795R C1orf94  1号染色体开放阅读框94抗体

hz-9796R C1orf96  1号染色体开放阅读框96抗体

hz-9797R C1orf103  1号染色体开放阅读框103抗体

hz-9798R C1orf41/HSB11  1号染色体开放阅读框41抗体

hz-9799R C1orf144  1号染色体开放阅读框144抗体

hz-0112M APP/ABPP  淀粉样肽前体蛋白抗体

hz-9801R C1orf157  1号染色体开放阅读框57抗体

hz-9802R C1orf180/AIDA  1号染色体开放阅读框80抗体

hz-0112R APP/ABPP  APP/ABPP淀粉样肽前体蛋白抗体

hz-0347R APP695 (CT)  淀粉样肽前体蛋白抗体（C端）

hz-9803R hzL4/C2orf180  限制过度增殖相关蛋白hzL4抗体