CD28抗体

英文名称    CD28    

中文名称    CD28抗体    

别    名    CD 28; CD28 antigen; CD28 molecule; MGC138290; T cell antigen CD28; T cell specific surface glycoprotein; T cell specific surface glycoprotein CD28; Tp44.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  干细胞  细胞粘附分子  细胞表面分子  淋巴细胞  t-淋巴细胞  b-淋巴细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 CD28抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    22kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from mouse CD28    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

CD28抗体产品介绍    background:

Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide MHC complexes, and the second is delivered by accessory or costimulating molecules through their counter receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ and CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells and on interferon gamma treated monocytes. The binding of B7 1/BB 1 molecules to CD28 is involved in T lymphocyte activation and in the initiation and maintenance of chronic inflammation.

Function:
Possibly involved in T-cell activation.

CD28抗体

hz-1136R synaptotagmin-2  突触结合蛋白相关基因2抗体

hz-1897R Synaptotagmin-4  突触结合蛋白4抗体

hz-3972R Synaptotagmin 5  突触结合蛋白5抗体

hz-1898R SPATA12  睾丸特异表达新基因5抗体

hz-1899R SRG11/Spata17  睾丸凋亡基因抗体

hz-3633R Synaptopodin  突触极蛋白synaptopodin抗体

hz-0635R SSA/52KDa Ro  核糖核蛋白抗原抗体

hz-0276R SSB/La  干燥症SSB/La抗体

hz-5818R Sulfatase 1  硫酸酯酶1抗体

hz-3857R SSDD/Steroid sulfatase  类固醇硫酸酯酶抗体

hz-3894R Sulfatase 2  硫酸酯酶2蛋白抗体

hz-3575R SSEA3  阶段特异性胚胎表面抗原-3抗体

hz-1381R AKAP12/Gravin  丝氨酸抑制蛋白激酶C底物抗体

hz-1702R CD15/Fut4/SSEA-1  阶段特异性胚胎表面抗原-1抗体

hz-1137R SSTR1  生长抑素受体1抗体

hz-1138R SSTR2  生长抑素受体2抗体

hz-1368R SSTR3  生长抑素受体3抗体

hz-1900R SSTR4  生长抑素受体4抗体

hz-1139R SSTR5  生长抑素受体5抗体

hz-3570R StAR/StARD1  促黄体激素诱导蛋白抗体

hz-3919R STARD5  促黄体激素诱导蛋白5抗体

hz-1317R STAT1  信号转导与转录激活因子1抗体

hz-1657R phospho-STAT1 (Tyr701)  磷酸化信号转导与转录激活因子1抗体

hz-3427R phospho-STAT1 (Ser727)  磷酸化信号转导与转录激活因子1抗体

hz-1140R STAT2  信号转导和转录激活因子2抗体

hz-3428R Phospho-Stat2 (Tyr690)  磷酸化信号转导和转录激活因子2抗体

hz-1901R STEAP1  前列腺跨膜上皮1抗原抗体

hz-1658R phospho-STAT3 (Tyr705)  磷酸化信号转导和转录激活因子3抗体