细胞色素P450单氧化酶抗体

英文名称    CYP450    

中文名称    细胞色素P450单氧化酶抗体    

别    名    Cytochrome P450 monooxygenase; CPR; CYPOR; DKFZp686G04235; FLJ26468; NADPH Cytochrome P450 Reductase; P450 Cytochrome Oxidoreductase; P450R; POR; CP2J3_RAT; Cytochrome P450 2J3.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500细胞色素P450单氧化酶抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    58kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from rat CYP450    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞色素P450单氧化酶抗体产品介绍    background:

Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.

Function:
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9-epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA).    

细胞色素P450单氧化酶抗体

hz-1992R mTOR/FRAP  雷帕霉素靶蛋白抗体

hz-3494R Phospho-FRAP1/mTOR(Ser2448)  磷酸化雷帕霉素靶蛋白抗体

hz-3495R Phospho-mTOR (Ser2481)  磷酸化雷帕霉素靶蛋白抗体

hz-5329R Phospho-mTOR (Tyr144)  磷酸化雷帕霉素靶蛋白抗体

hz-5330R Phospho-RhoA(Ser188)  磷酸化RhoA蛋白抗体

hz-5331R Phospho-mTOR (Thr2446)   磷酸化雷帕霉素靶蛋白抗体

hz-1724R MTLR  胃动素受体抗体

hz-5083R MTTP  微粒体甘油三酯转运蛋白

hz-5085R MVD  甲羟戊酸脱羧酶抗体

hz-1018R CA15-3/Muc1  粘蛋白-1/上皮膜抗原抗体

hz-1993R Muc2  粘蛋白-2/上皮膜抗原2抗体

hz-1525R mucin3/Muc3  粘蛋白-3抗体

hz-2414R mucin 5B/Muc5B  粘蛋白-5B抗体

hz-1994R Mucin 4/Muc4  粘蛋白-4抗体

hz-5086R MVK  甲羟戊酸激酶抗体

hz-3954R STXBP1/Munc18  神经突触前膜胞内蛋白18抗体

hz-5639R phospho-STXBP1(Ser515)  磷酸化神经突触前膜胞内蛋白抗体

hz-2539R MuRF1/Trim63  肌肉细胞特异性泛素蛋白连接酶1抗体

hz-1047R MyD88  髓样分化蛋白抗体

hz-2380R MYL9  肌球蛋白轻链9抗体

hz-4060R phospho-MYL9(Thr19)  磷酸化肌球蛋白轻链9抗体

hz-3658R NIPP1/ARD1  核抑制蛋白磷酸酶1抗体

hz-0337R Myelin Protein Zero  外周髓磷脂P0蛋白/P0蛋白抗体

hz-2032R PMP2  周围神经髓鞘蛋白2抗体

hz-2166R MYSM1  MYSM1抗体

hz-1267R MYOZ/MYOZ1  MYOZ抗体

hz-2442R MyoD1/Myf3  肌原调节蛋白抗体

hz-5499R phospho-MyoD1(Ser200)  磷酸化肌原调节蛋白抗体

hzt-0509M SM Myosin (Smooth Muscle)  人心肌肌凝蛋白(平滑肌) 小鼠单抗