周期素E抗体

英文名称    Cyclin E    

中文名称    周期素E抗体    

别    名    CCNE 1; CCNE; CCNE1; Cyclin E1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1; CCNE1_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  细胞周期蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500周期素E抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    45kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from rat Cyclin E    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素E抗体产品介绍    background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant (1) contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2. 

Subunit:
Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.    

周期素E抗体

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hz-1855R MMP-15  基质金属蛋白酶-15抗体

hz-1856R MMP-16  基质金属蛋白酶-16抗体

hz-0985R MMP-20  基质金属蛋白酶20抗体

hz-1862R MMP-17  基质金属蛋白酶-17抗体

hz-5787R MMP19  基质金属蛋白酶18/19

hz-5788R MMP20  基质金属蛋白酶20

hz-1991R MMP24/ MMP25/MMP21  基质金属蛋白酶-24抗体

hz-5874R MMP-22  基质金属蛋白酶22抗体

hz-5875R MMP-23  基质金属蛋白酶23抗体

hz-1377R MMP-26  基质金属蛋白酶-26抗体

hz-5876R MMP-28  基质金属蛋白酶28抗体

hz-1344R MMP-10  基质金属蛋白酶-10抗体

hz-1853R MMP-11  基质金属蛋白酶-11抗体

hz-1854R MMP-12  基质金属蛋白酶-12抗体

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hz-0426R MOG  髓鞘少树突胶质细胞糖蛋白抗体

hz-1802R Moesin  膜突蛋白抗体

hz-0774R Mouse IgA  兔抗小鼠IgA抗体

hz-1882R M-RAS/Mras  原癌基因M-ras抗体

hz-3832R RHEB  Ras蛋白脑组织同源类似物RHEB蛋白抗体

hz-3503R Mre11/HNGS1  DNA损伤关键蛋白Mre11抗体

hz-3293R Phospho-Mre11 (Ser676)  磷酸化DNA损伤关键蛋白Mre11抗体

hz-1061R MPO/c-ANCA  髓过氧化物酶抗体

hz-1850R MCR/NR3C2/Mineralocorticoid receptor  盐皮质激素受体抗体

hz-0657R MRP1/ABCC1  多药耐药相关蛋白1抗体

hz-1092R MRP2  多药耐药相关蛋白2抗体

hz-0656R MRP3  多药耐药相关蛋白3抗体