周期素D2抗体

英文名称    Cyclin D2    

中文名称    周期素D2抗体    

别    名    CCND 2; CCND2; CyclinD2; G1/S specific cyclin D2; KIAK0002; MGC102758; CCND2_HUMAN; G1/S-specific cyclin-D2.    

说 明 书    0.1ml  0.2ml  1ml    

研究领域    肿瘤  细胞生物  细胞周期蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素D2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    35kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from the middle of human Cyclin D2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素D2抗体产品介绍    background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Function:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.    

周期素D2抗体

hz-2992R MLK3/RHOE  丝氨酸/苏氨酸蛋白激酶MLK3抗体

hz-3280R Phospho-MLK3(Thr277/Ser281)  磷酸化丝氨酸/苏氨酸蛋白激酶MLK3抗体

hz-3950R MLX  转化因子样蛋白4抗体

hz-2797R MLC3F/MYL1/3  肌球蛋白轻链1/3抗体

hz-3295R Phospho-MYL(Ser19)  磷酸化肌球蛋白轻链2抗体

hz-2240R MYL3/Myosin light chain 3  肌球蛋白轻链3抗体

hz-4122R MAX protein  Myc基因相关X因子抗体

hz-5425R phospho-MAX protein(Tyr123)  磷酸化Myc基因相关X因子抗体

hz-3505R Myt1  髓鞘转录因子1抗体

hz-3296R Phospho-Myt1(Ser83)  磷酸化髓鞘转录因子1抗体

hz-4129R MYL6  肌球蛋白轻链6抗体

hz-5478R phospho-MYL6(Tyr29+Ser30)  磷酸化肌球蛋白轻链6抗体

hz-1044R MIF  巨噬细胞移动抑制因子抗体

hz-6255R JIP1/MAPK8IP1  丝裂原活化蛋白激酶8相互作用蛋白1

hz-1045R MIP-1 Alpha  巨噬细胞炎症因子1α抗体 MIP-1α

hz-1046R MIP-1 Beta/CCL4  巨噬细胞炎症因子1β 抗体 MIP-1β

hz-1989R MIP4/CCL18  巨噬细胞炎症蛋白18抗体

hz-1990R MITF  MITF相关转录因子抗体

hz-0424R MMP-1  基质金属蛋白酶-1抗体

hz-0463R MMP-1  基质金属蛋白酶-1抗体

hz-0412R MMP-2  基质金属蛋白酶-2抗体

hz-0413R MMP-3  基质金属蛋白酶3抗体

hz-0423R MMP-7  基质金属蛋白酶-7抗体

hz-1913R MMP-8  基质金属蛋白酶-8抗体

hz-0397R MMP-9  基质金属蛋白酶-9抗体

hz-2099R MMP-9  基质金属蛋白酶-9抗体

hz-4599R MMP-2  基质金属蛋白酶-2抗体

hz-4605R MMP-2  基质金属蛋白酶-2抗体

hz-4597R MMP-1  基质金属蛋白酶-1抗体

hz-0575R MMP-13  基质金属蛋白酶13抗体