周期素D1抗体

英文名称    Cyclin D1    

中文名称    周期素D1抗体    

别    名    Cyclin D1; CyclinD1; Cyclin-D1; B cell ccl/lymphoma 1; B cell leukemia 1; B-cell CLL/lymphoma 1; B-cell leukemia 1; B-cell lymphoma 1 protein; BCL-1; BCL1; BCL1 oncogene; CCND 1; CCND1; CCND1 protein; CCND1/FSTL3 fusion gene, included; CCND1/IGHG1 fusion gene; CCND1/IGHG1 fusion gene, included; CCND1/IGLC1 fusion gene, included; CCND1/PTH fusion gene, included; Parathyroid adenomatosis 1; PRAD1; FSTL3; CCND1_HUMAN; AI327039; B cell lymphoma 1 protein; BCL 1; BCL-1; BCL-1 oncogene; BCL1 oncogene; CCND1/FSTL3 fusion gene, included; cD1; Cyl 1; D11S287E; G1/S specific cyclin D1; G1/S-specific cyclin-D1.    

说 明 书    0.1ml  0.2ml  1ml    

研究领域    肿瘤  细胞生物  细胞周期蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素D1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    32kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Cyclin D1 N-terminus    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素D1抗体产品介绍    background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].

Function:
Regulatory component of the cyclin D1-CDK4 (DC) complexthat phosphorylates and inhibits members of the retinoblastoma (RB)protein family including RB1 and regulates the cell-cycle duringG(1)/S transition. Phosphorylation of RB1 allows dissociation ofthe transcription factor E2F from the RB/E2F complex and thesubsequent transcription of E2F target genes which are responsiblefor the progression through the G(1) phase. Hypophosphorylates RB1in early G(1) phase. Cyclin D-CDK4 complexes are major integratorsof various mitogenenic and antimitogenic signals. Also substratefor SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent mannerand repressing its transcriptional activity. Component of theternary complex, cyclin D1/CDK4/CDKN1B, required for nucleartranslocation and activity of the cyclin D-CDK4 complex.    

周期素D1抗体

hz-5481R phospho-MEF2C(Ser387)  磷酸化肌细胞增强因子2C抗体

hz-5482R phospho-MEF2C(Thr20)  磷酸化肌细胞增强因子2C抗体

hz-5483R phospho-MEF2C(Thr300)  磷酸化肌细胞增强因子2C抗体

hz-0815R Megsin  丝氨酸蛋白酶抑制剂B7抗体

hz-4136R MEF2D  肌细胞特异性增强因子2D抗体

hz-5501R phospho-MEF2D(Ser180)  磷酸化肌细胞特异性增强因子2D抗体

hz-5502R phospho-MEF2D(Ser444)  磷酸化肌细胞特异性增强因子2D抗体

hz-0904R Melamine  三聚氰胺抗体

hz-0939R Melamine  三聚氰胺抗体

hz-0051R Melanoma HMB45/Melanoma/Melan-A/MART-1  黑色素瘤相关抗原/黑色素-A抗体

hz-1759R Met Enkephalin  甲硫氨酸脑啡肽抗体

hz-1433R MEK1/MAPKK1/MEKK1  MEK1/MAPKK1抗体(N-端)

hz-1988R Menin/Men1  Menin抑癌蛋白抗体

hz-6189R phospho-alpha Adducin(Ser726)  磷酸化内收蛋白a1抗体

hz-0401R Metal ion transporter  拟南介金属离子转运蛋白抗体

hz-0557R Mfn1  线粒体融合蛋白1抗体

hz-1002R MGMT  O6甲基鸟嘌呤DNA甲基转移酶抗体

hz-1328R Metallothionein  金属硫蛋白抗体

hz-3885R Metallothionein 3  金属硫蛋白3抗体

hz-0900R LAMR1  层粘连蛋白受体1抗体（N端）

hz-1412R MTA1  肿瘤转移相关蛋白1抗体

hz-0901R LAMR1(CT)  层粘连蛋白受体1抗体（C端）

hz-2161R Myf6  生肌调节因子6抗体

hz-5101R MFAP3L  微丝相关蛋白3样抗体

hz-0832R MICA/MHC I  MHC I类链相关蛋白A/组织相容性复合物1抗体

hz-4120R MHC class I antigen B 15  组织相关抗原HLA-B15抗体

hz-0909R Microsporidia protien  蜜蜂微孢子虫蛋白抗体

hz-0761R Midnolin isoform Protein 1  中脑核仁蛋白1抗体

hz-0762R MIDN  中脑核仁蛋白抗体

hz-1849R Midkine  中期因子/肝素结合生长因子抗体