周期素C抗体

英文名称    Cyclin C    

中文名称    周期素C抗体    

别    名    CCNC; Cyclin-C; CycC; Cyclin C; hSRB11; SRB11 homolog; OTTHUMP00000016897; CCNC_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  染色质和核信号  细胞周期蛋白  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素C抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    33kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Cyclin C C-terminus    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素C抗体产品介绍    background:

Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.

Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. [SUBUNIT] Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.     

周期素C抗体

hz-1042R MCSF/M-CSF  巨噬细胞克隆刺激因子抗体

hz-3074R phospho-M-CSF Receptor(Tyr546)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3075R phospho CSF1R (Tyr699)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3076R phospho-M-CSF Receptor(Tyr708)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3077R phospho-CSF1R (Tyr723)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3078R phospho-M-CSF Receptor(Tyr809)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3079R phospho-CSF1R(Tyr923)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-1569R MCT1  单羧酸转运蛋白-1抗体

hz-1981R MCM2  微小染色体维持缺陷蛋白2抗体

hz-1982R MCM3  微小染色体维持缺陷蛋白3抗体

hz-2721R MCM5  微小染色体维持缺陷蛋白5抗体

hz-1983R MCM7  微小染色体维持缺陷蛋白7抗体

hz-1352R Mcl1/BCL2L3  髓样分化蛋白2抗体

hz-3265R Phospho-Mcl1 (Ser159/Thr163)  磷酸化髓样细胞白血病-1抗体

hz-3996R MDH1  可溶性苹果酸脱氢酶抗体

hz-1043R MDM2  双微体2癌基因抗体

hz-3266R Phospho-MDM2 (Ser166)  磷酸化双微体2癌基因抗体

hz-5470R Phospho-MDM2(Thr218)  磷酸化双微体2癌基因抗体

hz-5471R Phospho-MDM2(Ser186)  磷酸化双微体2癌基因抗体

hz-1468R MDR1/p-GP/CD243 (C-terminus)  多药耐药蛋白/P-糖蛋白抗体(C端)

hz-0563R MDR1/p-GP/CD243 (N-terminus)  多药耐药蛋白/P-糖蛋白抗体

hz-5915R MBD1/PCM1  甲基化CpG结合蛋白抗体

hz-3823R MeCP2  甲基化CpG结合蛋白2抗体

hz-1400R MEF2A  肌细胞增强因子2抗体

hz-3267R Phospho-MEF2A (Thr312)  磷酸化肌细胞增强因子2抗体

hz-3268R Phospho-MEF2A (Ser408)  磷酸化肌细胞增强因子2抗体

hz-4130R MEF2C  肌细胞增强因子2C抗体

hz-5479R phospho-MEF2C(Ser59)  磷酸化肌细胞增强因子2C抗体

hz-5480R phospho-MEF2C(Ser396)  磷酸化肌细胞增强因子2C抗体

hz-5485R Phospho-MEF2A(Thr319)  磷酸化肌细胞增强因子2抗体