周期素依赖性激酶7抗体

英文名称    CDK7    

中文名称    周期素依赖性激酶7抗体    

别    名    Cyclin H; MAT1; Cyclin Dependent Kinase 7; CAK1; MO15; CDKN7; serine/threonine kinase; STK1; serine/threonine protein kinase 1; MO15 homolog,Xenopus laevis, cdk-activating kinase; Cdk-activating kinase; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; 39 KDa protein kinase; CR4 protein kinase; CRK4.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  染色质和核信号  信号转导  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Bovine,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素依赖性激酶7抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CDK7 C-terminus    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素依赖性激酶7抗体产品介绍    background:

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008] 

Function:
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.    

周期素依赖性激酶7抗体

hz-11062R PSCDBP/CYTIP  胞粘蛋白结合调节蛋白抗体

hz-11063R Plakophilin 2  桥粒斑菲素蛋白2抗体

hz-11064R SPON2/M spondin/Mindin  细胞外基质底物反应蛋白2抗体

hz-11065R SNTG2/Syntrophin 5  肌蛋白结合蛋白γ2抗体

hz-11066R DOK6  胞浆接头蛋白Dok6抗体

hz-11067R TECTB  遗传性耳聋β-tectorin抗体

hz-11068R TNR/Tenascin-R  腱糖蛋白R抗体

hz-11069R procollagen type IIA  Ⅱ型胶原α1抗体

hz-11070R AMIGO1  粘附分子IgG样结构域蛋白1抗体

hz-11071R ANTXR2  炭疽毒素受体2抗体

hz-11072R ASTN2  星形肌动蛋白抗体

hz-11073R CDH18  钙粘附分子18抗体

hz-11074R CNTN4/AXCAM  轴突相关粘附分子抗体

hz-11075R CNTNAP3   接触蛋白相关蛋白3抗体

hz-11076R CNTNAP4  接触蛋白相关蛋白4抗体

hz-11077R Cadherin 8  钙粘附蛋白8抗体

hz-11078R Cadherin 8  钙粘附蛋白8抗体

hz-11079R Cadherin 9  钙粘附蛋白9抗体

hz-11080R MPZL2/EVA1  髓鞘蛋白P0样蛋白2抗体

hz-4589R HDL/high density lipoprotein  高密度脂蛋白抗体

hz-4231R ARSB  芳基硫酸酯酶B抗体

hz-11081R CDHF15/FAT3  钙粘蛋白15抗体

hz-11082R Neurotrimin/HNT  神经营养因子HNT抗体

hz-11083R Junctophilin 3  连接蛋白JPH3抗体

hz-11084R Junctophilin 4  连接蛋白JPH4抗体

hz-11085R PCDH7  原钙粘蛋白7抗体

hz-11086R JAMC  连接粘附分子C抗体

hz-11087R LRFN2/SALM1  神经突触粘附样分子1抗体

hz-11088R LRFN3/SALM4  神经突触粘附样分子4抗体

hz-11089R LRFN4  富含亮氨酸重复序列/Ⅲ型纤维连接蛋白4抗体

hz-11090R LRRC4B/NGL3  神经突触蛋白NGL3抗体

hz-11091R LSAMP  大脑边缘系统相关膜蛋白抗体

hz-11092R MDGA2  神经元膜糖蛋白锚定蛋白2抗体

hz-11093R Myelin PLP  髓磷酯髓鞘蛋白1抗体