周期素依赖性激酶6抗体

英文名称    CDK6    

中文名称    周期素依赖性激酶6抗体    

别    名    CDK 6; CDK6; Cell division protein kinase 6; Crk 2; Crk2; Cyclin dependent kinase 6; Cyclin-dependent kinase 6; MGC59692; p40; PLSTIRE; Serine/threonine-protein kinase PLSTIRE; STQTL11; CDK6_HUMAN; PLSTIRE; Serine/threonine protein kinase PLSTIRE.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  染色质和核信号  信号转导  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素依赖性激酶6抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CDK6 N-terminuse    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素依赖性激酶6抗体产品介绍    background:

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

Function:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.    

周期素依赖性激酶6抗体

hz-11029R MID2/RNF60/Midline-2  环指蛋白60抗体

hz-11030R RP1/DCDC4A  视网膜色素变性蛋白1抗体

hz-11031R STAU2  双链RNA结合蛋白Staufen2抗体

hz-11032R Gliomedin/COLM  神经胶质蛋白(肝癌相关基因2)抗体

hz-11033R KIF1B  驱动蛋白家族成员1B抗体

hz-11034R MYBPC1  肌球蛋白结合蛋白C抗体

hz-11036R Neurexin 1  轴突蛋白1(Neurexin 1α)抗体

hz-11037R TANC1  TANC1蛋白抗体

hz-11038R MYRIP/SLAC2-C  MYRIP蛋白抗体

hz-11039R Amisyn  突触融合结合蛋白6抗体

hz-11040R Bestrophin  卵黄状黄斑病蛋白抗体

hz-11041R Bestrophin 2  卵黄状黄斑病蛋白2抗体

hz-11042R Bestrophin 3  卵黄状黄斑病蛋白3抗体

hz-11043R Bestrophin 4  卵黄状黄斑病蛋白4抗体

hz-11045R C1QL1  补体组分1q子成分样蛋白1抗体

hz-11046R CHL1/CALL  神经细胞粘附分子CALL抗体

hz-11047R COL6A5/Collagen VI alpha 5  6型胶原蛋白α5抗体

hz-11049R CPA6  胰羧肽酶A6抗体

hz-11050R GJC2/Connexin 47  间隙连接蛋白47抗体

hz-4215R Sin3b  转录抑制蛋白Sin3b抗体

hz-11051R HAPLN2  透明质酸及粘蛋白2抗体

hz-11052R HAS3  透明质酸合成酶3抗体

hz-11053R KAL1  卡尔曼综合征基因1抗体

hz-11054R Keratocan  细胞角膜蛋白多糖抗体

hz-11055R Laminin alpha 4  层粘蛋白α4抗体(Lamininα4)

hz-11056R Laminin alpha 4  层粘蛋白α4抗体(Lamininα4)

hz-11057R Ligamentum Nuchae Elastin  项韧带弹性蛋白抗体

hz-11058R APBA3/Mint3/X11gamma  β淀粉样前体蛋白结合蛋白3抗体

hz-11059R NTN3/Netrin-3  轴突生长诱导因子3抗体

hz-4216R Sphingomyelin Synthase 1  鞘磷脂合成酶1抗体

hz-11060R OTOA/DFNB22  耳聋、常染色体隐性遗传22抗体

hz-11061R OLFM3/Optimedin  嗅球蛋白3抗体

hz-4217R SMS2/Sphingomyelin Synthase 2  鞘磷脂合成酶2抗体