半胱胺酸蛋白酶蛋白-12抗体

英文名称    Caspase-12    

中文名称    半胱胺酸蛋白酶蛋白-12抗体    

别    名    UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene); Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 半胱胺酸蛋白酶蛋白-12抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    46kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from the middle of human Caspase-12    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

半胱胺酸蛋白酶蛋白-12抗体产品介绍    background:

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

Function:
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.    

半胱胺酸蛋白酶蛋白-12抗体

hz-8355R UBE2D3  泛素蛋白连接酶D3抗体

hz-8356R UBE2D1  泛素蛋白连接酶D1抗体

hz-8357R UBE2C  泛素蛋白连接酶C抗体

hz-8358R KLHDC8A  KLHDC8A蛋白抗体

hz-8359R KLHDC9  KLHDC9蛋白抗体

hz-8360R LRRC2  LRRC2蛋白抗体

hz-8361R LRRC59  LRRC59蛋白抗体

hz-8362R LRRC41  LRRC41蛋白抗体

hz-8363R NIPA  间变性淋巴瘤激酶核相互作用伴侣蛋白抗体

hz-8364R phospho-NIPA(Ser354)  磷酸化间变性淋巴瘤激酶核相互作用伴侣蛋白抗体

hz-8365R RAB40B  RAS癌基因家族蛋白RAB40B抗体

hz-8366R RAB40A  RAS癌基因家族蛋白RAB40A抗体

hz-8367R RAB40C  RAS癌基因家族蛋白RAB40C抗体

hz-8368R EGR2  早期生长反应蛋白2抗体

hz-8369R Ube2L6  泛素载体蛋白L6抗体

hz-8370R Ube2H/UBCH2  泛素激活酶2H抗体

hz-8371R Ube2G1/UBC7  泛素蛋白连接酶G1抗体

hz-8372R UFC1  泛素结合酶UFC1抗体

hz-8373R UBCH6/UBE2E1  泛素蛋白连接酶E1抗体

hz-8374R UBC6e/UBE2J1  泛素结合酶E2J1抗体

hz-8375R UBE2A/UBE2B/RAD6  泛素结合酶E2蛋白A抗体

hz-8376R RNF160/ZNF294  环指蛋白160抗体

hz-8377R NFX1  核转录因子X盒结合蛋白1抗体

hz-8378R NCE2  泛素结合酶E2F抗体

hz-8379R HIP2  泛素蛋白连接酶E2抗体

hz-8380R UBE2O/E2 230K  泛素结合酶E2O抗体

hz-4169R PTK9/TWF1  蛋白酪氨酸激酶9抗体

hz-5613R phospho-PTK9/TWF1(Tyr321)  磷酸化蛋白酪氨酸激酶9抗体

hz-8381R UBE2J2  泛素蛋白连接酶J2抗体

hz-8382R UBE2M  泛素蛋白连接酶M抗体

hz-8383R UBE2Q1  泛素蛋白连接酶Q1抗体