天冬氨酸-胱氨酸特异性蛋白酶家族抗体

英文名称    Caspase-1 P10    

中文名称    天冬氨酸-胱氨酸特异性蛋白酶家族抗体    

别    名    caspase-1 isoform alpha p10 subunit; CASP 1; CASP1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; ICE; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BC; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme. CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; Caspase-1 subunit p10.    

说 明 书    0.1ml  0.2ml  1ml    

研究领域    肿瘤  细胞生物  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 天冬氨酸-胱氨酸特异性蛋白酶家族抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    10/45kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Caspase-1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

天冬氨酸-胱氨酸特异性蛋白酶家族抗体产品介绍    background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

Function:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.    

天冬氨酸-胱氨酸特异性蛋白酶家族抗体

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hz-6160R VAV2  癌基因VAV2抗体

hz-8291R DPY19L2  DPY19L2蛋白抗体

hz-8292R DPY19L4  DPY19L4蛋白抗体

hz-8293R DQX1  DQX1蛋白抗体

hz-8294R DPP9/DPRP2  二肽基肽酶9抗体

hz-8295R DPP8/DPRP1  二肽基肽酶8抗体

hz-8296R Matriptase 2  膜型丝氨酸蛋白酶2抗体

hz-8297R CYBR1  细胞色素B还原酶1抗体

hz-8298R UQCRC1  辅酶细胞色素C还原酶核心蛋白1抗体

hz-8299R TXNRD1  硫氧环蛋白还原酶1抗体

hz-8300R PRDX2/Peroxiredoxin-SO3  硫氧还蛋白过氧化物酶2

hz-8301R NDUFA9  NDUFA9蛋白抗体

hz-8302R GLT8D2  糖基转移酶GLT8D2抗体

hz-8303R LGI4  含亮氨酸神经胶质瘤失活蛋白4抗体

hz-8304R MTGR1  髓易位基因相关蛋白1抗体

hz-8305R LYL1  淋巴细胞性白血病相关序列1抗体

hz-8306R Properdin  P因子/备解素抗体

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hz-8309R ANKRD54  锚蛋白重复域54抗体

hz-8310R COX4NB  COX4NB蛋白抗体

hz-8312R FAM82A1  微管动力调节蛋白FAM82A抗体

hz-8313R FAM46D/CT112  肿瘤/睾丸抗原112抗体

hz-8314R FAM50B  FAM50B蛋白抗体

hz-8315R FAM50C  FAM50C蛋白抗体

hz-8316R HDHD1  HDHD1蛋白抗体

hz-8317R HDHD2/IER3IP1  HDHD2蛋白抗体

hz-8318R HDHD3  HDHD3蛋白抗体

hz-8319R HDHD2B/LHPP  HDHD2B蛋白抗体

hz-8320R HEATR3  HEATR3蛋白抗体

hz-8321R HEATR6  乳腺癌增强蛋白抗体

hz-8322R Proteasome 19S S5A  26S蛋白酶调节亚型S5a抗体