2’,3’-环腺苷酸-3’-磷酸二酯酶抗体

英文名称    CNPase    

中文名称    2’,3’-环腺苷酸-3’-磷酸二酯酶抗体    

别    名    2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase; Cnp; Cnp-1; Cnp1; 2''; 2'3' cyclic nucleotide 3' phosphodiesterase; 2'3'-cyclic-nucleotide 3'-phosphodiesterase; 3''-cyclic-nucleotide 3''-phosphodiesterase; CN37_HUMAN; CNP 1; CNP; CNP1; CNPase.    

说 明 书    0.1ml  0.2ml      

研究领域    神经生物学  细胞类型标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse, Rabbit, Bovine,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 2’,3’-环腺苷酸-3’-磷酸二酯酶抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CNPase    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

2’,3’-环腺苷酸-3’-磷酸二酯酶抗体产品介绍    background:

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase). This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.

Function:
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.    

2’,3’-环腺苷酸-3’-磷酸二酯酶抗体

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hz-7976R ATXN7L2  共济失调蛋白7样2抗体

hz-7977R BCNP  B淋巴细胞新型蛋白1抗体

hz-7978R BEX4  脑表达X连锁蛋白4抗体

hz-7940R ABCA5  三磷酸腺苷结合盒转运蛋白A亚基5抗体

hz-7979R BTBD7  BTB/POZ结构域蛋白7抗体

hz-7980R GUSB/beta glucuronidase  β葡萄糖醛酸苷酶抗体

hz-7981R CA13  碳酸酐酶

hz-7982R HOXC9  同源盒蛋白HOXC9抗体

hz-7983R CA6  碳酸酐酶6抗体

hz-7984R CA7  碳酸酐酶7抗体

hz-7985R CCBE1  胶原蛋白和钙结合表皮生长因子结构域1抗体

hz-7986R CCDC102B  卷曲螺旋结构域蛋白102B抗体

hz-7987R CCDC16/ZNF83  卷曲螺旋结构域蛋白16抗体

hz-7988R CCDC21  卷曲螺旋结构域蛋白21抗体

hz-7989R CCDC52  卷曲螺旋结构域蛋白52抗体

hz-7990R CCDC6  卷曲螺旋结构域蛋白6抗体(乳头状甲状腺癌编码蛋白)

hz-7991R CCDC7  卷曲螺旋结构域蛋白7抗体

hz-7992R CCDC80  卷曲螺旋结构域蛋白80抗体

hz-7993R CD163L1  CD163蛋白样1抗体

hz-7994R CDAN1  先天性红细胞生成异常性贫血蛋白1抗体

hz-7995R CDK2AP2  细胞周期素依赖激酶2相关蛋白2抗体

hz-7996R CEACAM21  癌胚抗原相关细胞粘附分子21抗体

hz-7997R CDKAL1  周期素依赖性激酶5调节蛋白1样蛋白1抗体

hz-7998R CEACAM16/CEAL2  癌胚抗原相关细胞粘附分子16抗体

hz-7999R CEACAM19/CEAL1  癌胚抗原相关细胞粘附分子19抗体

hz-8012R ADCK5  ADCK5蛋白抗体

hz-8013R ITGB1BP2/CHORDC3  整合素β1结合蛋白2抗体

hz-8014R CLDND2  膜蛋白CLDND2抗体

hz-8015R CLLD7  鸟嘌呤核苷酸交换因子CLLD7抗体