细胞表面趋化因子受体4抗体

英文名称    CXCR4    

中文名称    细胞表面趋化因子受体4抗体    

别    名    C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Stromal cell-derived factor 1 receptor; SDF-1 receptor; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; CD184 antigen; CXCR4_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  细胞膜受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 细胞表面趋化因子受体4抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from the middle of human CD184 (211-254aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞表面趋化因子受体4抗体产品介绍    background:

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Monomer. Can form dimers.

Function:
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.    

细胞表面趋化因子受体4抗体

hz-7710R CENPP  着丝粒蛋白P抗体

hz-7711R PCNT/Pericentrin  中心粒周蛋白抗体

hz-7712R Importin4/RanBP4  核蛋白4抗体（Ran结合蛋白4）

hz-7713R MIS12  染色体及有丝分裂蛋白MIS12抗体

hz-7714R CDCA1/Nuf2  细胞分裂周期相关蛋白1抗体

hz-7715R Importin 9/RanBP9  核蛋白9抗体（Ran结合蛋白M）

hz-7716R SPC25  纺锤体极点构成蛋白25抗体

hz-7717R CDCA5/Sororin  细胞分裂周期相关蛋白5抗体

hz-7718R CAPD2/CNAP1  染色体相关蛋白2抗体

hz-7719R KRG2/DDX11  角质细胞生长因子调节蛋白2抗体

hz-7720R DSCC1  DSCC1蛋白抗体

hz-5285R phospho-CARM1(Ser228)  磷酸化蛋白精氨酸N甲基4抗体

hz-5575R phospho-PRKAA2(Ser173)  腺苷单磷酸活化蛋白激酶α2抗体

hz-7721R CAPG2/NCAPG2  染色体相关蛋白2抗体

hz-7722R APRIN/PDS5B  雄激素诱导增殖抑制蛋白抗体

hz-7723R REC8  减数分裂重组蛋白家族REC8抗体

hz-7724R SA1/Nuclear protein stromal antigen 1  粘结蛋白SA1抗体

hz-7725R SA2  粘结蛋白SA2抗体

hz-7726R phospho-REC8(Ser251)  磷酸化减数分裂重组蛋白家族REC8抗体

hz-7727R SMC2  染色体结构维持蛋白2抗体

hz-7728R SMC4  染色体结构维持蛋白4抗体

hz-7729R SMC5  染色体结构维持蛋白5抗体

hz-7730R SMC6  染色体结构维持蛋白6抗体

hz-7731R TRIP1/PSMC5  甲状腺受体相互作用蛋白1抗体

hz-7732R Separase  纺锤体级以外蛋白样1抗体

hz-7733R WAPL  EBV核蛋白2抗体

hz-7734R CAPD3/hCAP-D3  浓缩素2复合亚基D3抗体

hz-7735R AMSH  信号转导衔接结合蛋白抗体

hz-7736R ASB3  锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体

hz-7737R EIF2C1/Ago1  真核翻译起始因子2C1抗体

hz-7738R Anillin  胞环蛋白肌动蛋白结合蛋白抗体

hz-7739R BIN3  细胞骨架衔接蛋白BIN3抗体