上皮钙粘附分子抗体

英文名称    E cadherin    

中文名称    上皮钙粘附分子抗体    

别    名    E-cadherin; anion exchanger protein 3; Arc 1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 234; CD324; CD324 antigen; CDH1; CDHE; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin; CADH1_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    免疫学  发育生物学  信号转导  干细胞  通道蛋白  细胞粘附分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 上皮钙粘附分子抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    80kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human E-cadherin C-terminus    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

上皮钙粘附分子抗体产品介绍    background:

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as ∫-catenin, to regulate cadherin function.

Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.    

上皮钙粘附分子抗体

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hz-7651R DNase I  脱氧核糖核酸酶1抗体

hz-7652R DNase II  脱氧核糖核酸酶2抗体

hz-7653R DNase gamma  脱氧核糖核酸酶γ抗体

hz-7654R TIP30  TIP30蛋白抗体

hz-7655R AMID/AIFM2  线粒体凋亡诱导因子2抗体

hz-7656R ATAD5  染色体脆弱性相关基因抗体

hz-7657R BAT3/BAG6  Bcl2相关抗凋亡基因6抗体

hz-7658R CTNNBL1/Beta catenin like 1  β连环蛋白样蛋白1抗体

hz-7659R DATF1  死亡相关转录因子1抗体

hz-7660R TFDP2/DP2  转录因子E2F二聚体蛋白2抗体

hz-7661R EAF2  睾酮调节细胞凋亡诱导和肿瘤抑制基因抗体

hz-7662R FLI1  尤文肉瘤FLI1蛋白抗体

hz-7663R MDMX  MDM2样P53蛋白结合抗体

hz-7664R TMUB1  跨膜和泛素样结构域蛋白1抗体

hz-7665R NUP50  核孔蛋白50抗体

hz-7666R PDCD2L/MGC13096  程序性细胞死亡2抗体

hz-7667R SLTM  转绿调节因子SLTM抗体

hz-7668R GPR65  G蛋白偶联受体65抗体

hz-7669R AX2R/LOC389289  膜粘连蛋白2受体抗体

hz-7671R NADE/NGFRAP1  神经生长因子受体相关蛋白1抗体

hz-7672R NRH2  死亡结构域蛋白NRH2抗体

hz-7673R PGRPS  肽聚糖识别蛋白1抗体

hz-7674R Porimin  前细胞胀亡受体诱导膜损伤蛋白抗体

hz-7676R TRAF7  肿瘤坏死因子受体相关因子7抗体

hz-7677R ZDHHC16  细胞凋亡调控蛋白ZDHHC16抗体

hz-7678R DR6/CD358  肿瘤细胞调亡素/肿瘤坏死因子受体死亡受体6抗体

hz-7679R BCCIP/TOK1  乳腺癌易感基因2和p21蛋白抑制因子抗体

hz-2409R Amphiphysin  神经元突触前膜蛋白抗体

hz-7681R WISP39/FKBPL  p21调控蛋白WISP39抗体

hz-7682R RBM38  RNA结合蛋白38抗体