乳腺癌易感基因2相关蛋白抗体

英文名称    BRAF35    

中文名称    乳腺癌易感基因2相关蛋白抗体    

别    名    BRAF25; BRAF35; BRCA 2 Associated Factor (35kDa); BRCA2 associated factor 35; BRCA2-associated factor 35; High Mobility Group Protein 20B; HM20B_HUMAN; HMG 20B; HMG box containing protein 20B; HMG box-containing protein 20B; HMG domain-containing protein 2; HMG domain-containing protein HMGX2; hmg20b; HMGX2; PP7706; pp8857; SMARCE1 related protein; SMARCE1-related protein; SMARCE1r; sox like; Sox like transcriptional factor; Sox-like transcriptional factor; SOXL; Structural DNA binding protein BRAF35; Structural DNA-binding protein BRAF35; SWI/SNF related; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily E member 1 related; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 乳腺癌易感基因2相关蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    36kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human BRAF35    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

乳腺癌易感基因2相关蛋白抗体产品介绍    background:

The breast cancer susceptibility gene (BRCA1) localizes to chromosome 17q. Mutations within this gene account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer, but unlike BRCA1, BRCA2 does not confer a substantially elevated risk of ovarian cancer. The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2, which associates with condensed chromatin during histone H3 phosphorylation. BRAF35 expression levels are highest in proliferating tissues and parallel BRCA2 expression patterns. The structure of BRAF35 includes a kinesin-like coiled coil domain and a nonspecific DNA binding HMG domain. The chromatin localization of BRAF35 and antibody microinjection studies indicate a role for the BRAF35/BRCA2 complex in cell cycle regulation.

Function:
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.    

乳腺癌易感基因2相关蛋白抗体

hz-6011R HACE1  E3泛素蛋白连接酶HACE1抗体

hz-6014R SMARCA6/HELLS  淋巴特异性解旋酶抗体

hz-6015R SMARCA1/SNF2L  解旋酶SNF2L抗体

hz-6017R ACBD6  酰基辅酶A结合结构域蛋白6抗体

hz-6018R ACVR1B/ALK4  激活素A受体1B抗体

hz-6019R ACY1/Aminoacylase 1  氨基酰化酶1抗体

hz-6020R ACVRL1/ALK1  激活素受体样激酶1抗体

hz-6021R ASAH2  酰基鞘氨醇脱酰酶2抗体

hz-6022R ASAM/ACAM  脂肪细胞特异性粘附分子抗体

hz-6024R CARPX/CA10  碳酸酐酶相关蛋白抗体（脑蛋白15）

hz-6025R CA12  碳酸酐酶12抗体

hz-6028R IGFR3/CD16  FC段γ受体3/免疫球蛋白G Fc段受体III抗体

hz-6030R CD200/MOX1  膜糖蛋白CD200抗体

hz-6032R CD66c/CEACAM6  癌胚抗原相关细胞粘附分子抗体

hz-6034R CPA1/Carboxypeptidase A  胰羧肽酶A1抗体

hz-6035R CPA2/Carboxypeptidase A2  羧肽酶A2抗体

hz-6036R CPB1/Carboxypeptidase B1  胰羧肽酶B1抗体

hz-6037R CPEB1  细胞质多聚腺苷酸结合蛋白1抗体

hz-6042R Cystatin E/M  半胱氨酸蛋白酶抑制剂6抗体

hz-6038R CRABP2  细胞维甲酸结合蛋白2抗体

hz-6039R CST7/Cystatin F  半胱氨酸蛋白酶抑制剂7抗体

hz-6043R NBL1/DAND1  神经母细胞瘤抑瘤蛋白1抗体

hz-6044R DLL4/Delta 4  Notch信号通路Delta样配体4抗体

hz-6045R DPP2  溶酶体丝氨酸蛋白酶DPP2抗体

hz-6050R FSTL1/FRP  卵泡相关蛋白1

hz-6051R HPGD/PGDH1/Prostaglandin dhzydrogenase 1  前列腺素脱氢酶1抗体

hz-6052R HPRG/HRG  组氨酸富含脯氨酸糖蛋白抗体

hz-6053R Hhzopexin/HPX  糖蛋白β-1B抗体

hz-6055R LRPAP1/MRAP  脂蛋白受体相关蛋白抗体（低密度脂蛋白相关蛋白的相关蛋白1）