血型Lewis A抗原抗体

英文名称    Blood Group Lewis a    

中文名称    血型Lewis A抗原抗体    

别    名    Lewis A antigen.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  糖蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 血型Lewis A抗原抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    42kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Blood Group Lewis a    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

血型Lewis A抗原抗体产品介绍    background:

Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. Fucosyltransferases catalyze the covalent association of fucose to different positional linkages in sugar acceptor molecules. The carbohydrate moieties generated and covalently attached to cell surfaces are necessary to ensure a surface contour that satisfies physiological roles, which are reliant on adhesion molecules such as Selectins (1-3). Hematopoietic lineages rely on Fucosyltransferases to confer a surface carbohydrate phenotype, which mediates proper cell adhesion molecule recruitment and cell trafficking (4-6). Blood Group Lewis a is a carbohydrate determinant carried on both glycolipids and glycoproteins.

Function:
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links    

血型Lewis A抗原抗体

hz-4083R phospho-c-Abl(Tyr134)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3032R phospho-c-Abl(Tyr412)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3041R phospho-c-Abl(Tyr245)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3042R phospho-c-Abl(Tyr204)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3044R phospho-c-Abl(Ser735)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-3071R phospho-c-Abl(Tyr89)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4084R phospho-c-Abl(Tyr251)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4085R phospho-c-Abl(Tyr272)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4086R phospho-c-Abl(Tyr276)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-4087R SPTLC1  丝氨酸棕榈酰转移酶1抗体

hz-4088R SLC27A5  脂肪酸转运蛋白5抗体

hz-2932R Clathrin heavy chain/Clathrin HC  网格蛋白重链抗体

hz-2933R RAB-14  RAS相关蛋白癌基因Rab14抗体

hz-2936R ARHG7  p21活化蛋白激酶ARHG7抗体

hz-2938R TdT/DNTT  末端脱氧核苷酸转移酶抗体

hz-5183R phospho-c-Abl(Thr754)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-2940R FUCA1/Alpha L fucosidase I  α-L岩藻糖苷酶抗体

hz-2941R TNFR1/TNF Receptor I  肿瘤坏死因子受体1抗体

hz-2942R HHV8/ORF K14  人类疱疹病毒8 ORF14抗体

hz-2943R ShzA6D  轴突导向因子ShzA6D抗体

hz-2944R plant lectin B4/IB4  植物凝集素IB4

hz-2945R SNX1/Sorting nexin1  分选连接蛋白1抗体

hz-2947R ERG25  甲基固醇羟化酶单加氧酶1抗体

hz-5184R phospho-c-Abl(Tyr283)  磷酸化非受体酪氨酸激酶c-Abl抗体

hz-2950R Cytosine deaminase  胞嘧啶脱氨酶抗体

hz-2951R SQSTM1/p62  泛素结合蛋白P62抗体

hz-2952R NFAT4  核因子活化T细胞胞浆蛋白3抗体

hz-2953R Exportin 1/CRM1  染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体

hz-2954R IKZF3  锌指蛋白Aiolos抗体

hz-2955R C3a Receptor/C3aR  过敏毒素C3受体/补体C3受体抗体