英文名称 Blood Group Lewis a
中文名称 血型Lewis A抗原抗体
别 名 Lewis A antigen.
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 糖蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 血型Lewis A抗原抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Blood Group Lewis a
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
血型Lewis A抗原抗体产品介绍 background:
Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. Fucosyltransferases catalyze the covalent association of fucose to different positional linkages in sugar acceptor molecules. The carbohydrate moieties generated and covalently attached to cell surfaces are necessary to ensure a surface contour that satisfies physiological roles, which are reliant on adhesion molecules such as Selectins (1-3). Hematopoietic lineages rely on Fucosyltransferases to confer a surface carbohydrate phenotype, which mediates proper cell adhesion molecule recruitment and cell trafficking (4-6). Blood Group Lewis a is a carbohydrate determinant carried on both glycolipids and glycoproteins.
Function:
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links
血型Lewis A抗原抗体
hz-4083R phospho-c-Abl(Tyr134) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3032R phospho-c-Abl(Tyr412) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3041R phospho-c-Abl(Tyr245) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3042R phospho-c-Abl(Tyr204) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3044R phospho-c-Abl(Ser735) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-3071R phospho-c-Abl(Tyr89) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4084R phospho-c-Abl(Tyr251) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4085R phospho-c-Abl(Tyr272) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4086R phospho-c-Abl(Tyr276) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-4087R SPTLC1 丝氨酸棕榈酰转移酶1抗体
hz-4088R SLC27A5 脂肪酸转运蛋白5抗体
hz-2932R Clathrin heavy chain/Clathrin HC 网格蛋白重链抗体
hz-2933R RAB-14 RAS相关蛋白癌基因Rab14抗体
hz-2936R ARHG7 p21活化蛋白激酶ARHG7抗体
hz-2938R TdT/DNTT 末端脱氧核苷酸转移酶抗体
hz-5183R phospho-c-Abl(Thr754) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-2940R FUCA1/Alpha L fucosidase I α-L岩藻糖苷酶抗体
hz-2941R TNFR1/TNF Receptor I 肿瘤坏死因子受体1抗体
hz-2942R HHV8/ORF K14 人类疱疹病毒8 ORF14抗体
hz-2943R ShzA6D 轴突导向因子ShzA6D抗体
hz-2944R plant lectin B4/IB4 植物凝集素IB4
hz-2945R SNX1/Sorting nexin1 分选连接蛋白1抗体
hz-2947R ERG25 甲基固醇羟化酶单加氧酶1抗体
hz-5184R phospho-c-Abl(Tyr283) 磷酸化非受体酪氨酸激酶c-Abl抗体
hz-2950R Cytosine deaminase 胞嘧啶脱氨酶抗体
hz-2951R SQSTM1/p62 泛素结合蛋白P62抗体
hz-2952R NFAT4 核因子活化T细胞胞浆蛋白3抗体
hz-2953R Exportin 1/CRM1 染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体
hz-2954R IKZF3 锌指蛋白Aiolos抗体
hz-2955R C3a Receptor/C3aR 过敏毒素C3受体/补体C3受体抗体
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