乳腺癌易感基因复合物亚基蛋白3抗体

英文名称    BRCC3    

中文名称    乳腺癌易感基因复合物亚基蛋白3抗体    

别    名    BRCA1-A complex subunit BRCC36; BRCA1/BRCA2 containing complex subunit 3; BRCA1/BRCA2 containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; Brcc3; BRCC3_HUMAN; BRCC36; BRISC complex subunit BRCC36; C6.1A; Chromosome X open reading frame 53; CXorf53; Lys-63-specific deubiquitinase BRCC36.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500乳腺癌易感基因复合物亚基蛋白3抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    36kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human BRCC3/BRCC36    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

乳腺癌易感基因复合物亚基蛋白3抗体产品介绍    background:

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Function:
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.    

乳腺癌易感基因复合物亚基蛋白3抗体公司更多热销抗体产品如下：

hz-1035P CD86/B7-2  CD86抗原

hz-1341P Cdc2/P34CDC2/CDK1(Cell division control protein 2)  周期素依赖激酶1抗原

hz-1448P CD339/Jagged1  CD339/Jagged1抗原

hz-1392P Cdc34 peptide  细胞周期调控因子34抗原

hz-0542P CDK1 (Cyclin-Dependent Kinase 1)  周期素依赖性激酶1抗原

hz-2076PB METH/BSA (Methamphetamine/BSA)  冰毒/甲基苯丙胺与牛血清蛋白偶联物

hz-0559P CDK5(Cyclin Dependent Kinase 5)  周期素依赖性激酶5抗原

hz-0568P CDK6 (Cyclin Dependent Kinase 6)  周期素依赖性激酶6抗原

hz-0569P CDK7/Cyclin H/MAT1  周期素依赖性激酶7抗原

hz-0570P CDK8(Cyclin Dependent Kinase 8)  周期素依赖性激酶8抗原

hz-0538P Cdkn1c/p57/Kip2 (Cyclindependent kinase inhibitor 1C)  周期蛋白依赖激酶抑制因子1C抗原

hz-1093P CGP-39/YKL-40(Chitinase-3-like protein 1 )  软骨糖蛋白39（多肽）

hz-0719P CEA(Carcinohzbryonic Antigen )peptide  人癌胚抗原抗原

hz-2080P Cecropin  抗菌肽/天蚕素（多肽）

hz-2048P HER2 receptor(erbB-2 isoform 2)  c-erbB-2受体抗原

hz-1454P ErbB-3/HER3(Epidermal growth factor receptor3)  表皮生长因子受体3(抗原)

hz-1085P C-erbB-4/HER4/erbB-4 (epidermal growth factor receptor4)  c-erbB-4癌基因抗原

hz-1277P CFTR(cystic fibrosis transmhzbrane conductance regulator)  囊性纤维化跨膜转运调节因子抗原

hz-0775P CG6856-PA peptide  CG6856-PA抗原

hz-0539P CGA(Chromogranin A)  嗜铬粒素A抗原

hz-0543P CGB(Chromogranin B)  嗜铬粒素B抗原

hz-1150P ChRM1(muscarinic acetylcholine receptor)  毒蕈碱型乙酰胆碱受体M1抗原

hz-1289P ChRM3 peptide  毒蕈碱型乙酰胆碱受体M3抗原

hz-1059P CK18(Cytokeratin 18)  细胞角蛋白18(多肽)

hz-2043P CK18 peptide  细胞角蛋白18多肽抗原

hz-1339P CK18(Cytokeratin 18)  细胞角蛋白18抗原（C端）

hz-1792P CK14/17/42/10 peptide  细胞角蛋白14抗原

hz-1270P CK16(Cytokeratin 16)  细胞角蛋白16抗原

hz-1431P CK17(Cytokeratin 17)  细胞角蛋白17抗原