英文名称 BMPR1B
中文名称 骨形态发生蛋白受体1B抗体
别 名 BMPR-IB; Activin receptor like kinase 6; Acvrlk6; ALK 6; ALK6; alk6tr; BMP type-1B receptor; BMPR IB; BMPR-1B; Bmpr1b; BMPRIB; BMR1B_HUMAN; Bone morphogenetic protein receptor type 1B; Bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; BR 1b; BR1b; CDw 293; CDw293; CDw293 antigen; CFK 43a; CFK43a; Serine/threonine receptor kinase; zALK 6; zALK6.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 信号转导 干细胞 转录调节因子 激酶和磷酸酶 细胞表面分子 细胞外基质 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, .
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 骨形态发生蛋白受体1B抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human BMPR1B
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
骨形态发生蛋白受体1B抗体产品介绍 background:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
Involvement in disease; Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA). Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers).
Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo.
Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
骨形态发生蛋白受体1B抗体公司更多热销抗体产品如下:
hz-0297R-AP Rabbit Anti-human IgG/AP 碱性磷酸酶(AP)标记的兔抗人IgG
hz-0297R-HRP Rabbit Anti-human IgG/HRP 辣根过氧化物酶标记的兔抗人IgG
hz-0297R-hzy3 Rabbit Anti-human IgG/Cy3 Cy3标记的兔抗人IgG
hz-0297R-hzy5 Rabbit Anti-human IgG/Cy5 Cy5标记的兔抗人IgG
hz-0297R-PE Rabbit Anti-human IgG/PE PE标记的兔抗人IgG
hz-0297R-PE-hzy3 Rabbit Anti-human IgG/PE-Cy3 PE-Cy3标记的兔抗人IgG
hz-0297R-PE-hzY5 Rabbit Anti-human IgG/PE-CY5 PE-CY5标记的兔抗人IgG
hz-0297R-APhz Rabbit Anti-human IgG/APC APC标记的兔抗人IgG
hz-0297R-AF350 Rabbit Anti-human IgG/Alexa Fluor 350 Alexa Fluor 350标记的兔抗人IgG
hz-0297R-AF488 Rabbit Anti-human IgG/Alexa Fluor 488 Alexa Fluor 488标记的兔抗人IgG
hz-0297R-AF555 Rabbit Anti-human IgG/Alexa Fluor 555 Alexa Fluor 555标记的兔抗人IgG
hz-0297R-AF647 Rabbit Anti-human IgG/Alexa Fluor 647 Alexa Fluor 647标记的兔抗人IgG
hz-0297R-PE-hzy5.5 Rabbit Anti-human IgG/PE-Cy5.5 PE-Cy5.5标记的兔抗人IgG
hz-0297R-PE-hzy7 Rabbit Anti-human IgG/PE-Cy7 PE-Cy7标记的兔抗人IgG
hz-0297R-hzy5.5 Rabbit Anti-human IgG/Cy5.5 Cy5.5标记的兔抗人IgG
hz-0297R-hzy7 Rabbit Anti-human IgG/Cy7 Cy7标记的兔抗人IgG
hz-0297R-RBIThz Rabbit Anti-human IgG/RBITC 罗丹明标记的兔抗人IgG
hz-0297R-Gold Rabbit Anti-human IgG/Gold 胶体金标记的兔抗人IgG
hz-0297R-FIThz Rabbit Anti-human IgG/FITC FITC标记的兔抗人IgG
hz-0345R-FIThz Rabbit Anti-human IgM/FITC FITC标记的兔抗人IgM
hz-0345R-hzy3 Rabbit Anti-human IgM/Cy3 Cy3标记的兔抗人IgM
hz-0345R-hzy5 Rabbit Anti-human IgM/Cy5 Cy5标记的兔抗人IgM
hz-0345R-hzy5.5 Rabbit Anti-human IgM/Cy5.5 Cy5.5标记的兔抗人IgM
hz-0345R-hzy7 Rabbit Anti-human IgM/Cy7 Cy7标记的兔抗人IgM
hz-0345R-PE Rabbit Anti-human IgM/PE PE标记的兔抗人IgM
hz-0345R-PE-hzy3 Rabbit Anti-human IgM/PE-Cy3 PE-Cy3标记的兔抗人IgM
hz-0345R-PE-hzY5 Rabbit Anti-human IgM/PE-CY5 PE-CY5标记的兔抗人IgM
hz-0345R-APhz Rabbit Anti-human IgM/APC APC标记的兔抗人IgM
骨形态发生蛋白受体1B抗体 信息由上海沪震生物科技有限公司为您提供,如您想了解更多关于骨形态发生蛋白受体1B抗体 报价、型号、参数等信息,欢迎来电或留言咨询。除供应骨形态发生蛋白受体1B抗体 外,上海沪震生物科技有限公司还可为您提供p27Kip1 (Ab-10)抗体、Chk2 抗体、p90RSK (Ab-348) 抗体等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。