乳腺癌易感基因环状结构域蛋白抗体

英文名称    BARD1    

中文名称    乳腺癌易感基因环状结构域蛋白抗体    

别    名    BARD-1; Bard1; Bard 1; BARD1_HUMAN; BRCA1 associated RING domain 1; BRCA1 associated RING domain gene 1; BRCA1 associated RING domain protein 1; BRCA1-associated RING domain protein 1.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  染色质和核信号  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 乳腺癌易感基因环状结构域蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    85kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human BARD1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

乳腺癌易感基因环状结构域蛋白抗体产品介绍    background:

BRCA1 Associated RING Domain gene 1 (BARD1) interacts with the N terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N terminal RING motif and the C terminal BRCT domain. The RING motif is a cysteine rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. BARD1 also plays a role in mediating apoptotic stress and p53 dependent.

Subunit:
Homo- and heterodimer. Heterodimer    

乳腺癌易感基因环状结构域蛋白抗体公司更多热销抗体产品如下：

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hz-1178P PAR-2 (Protease-activated receptors-2)  蛋白酶激活受体-2抗原

hz-1196P PAR4 (protease-activated receptor 4)  蛋白酶活化受体4/前列腺细胞凋亡反应蛋白4抗原

hz-2138P PARP(poly ADP-ribose polymerase)N-Terminus  多腺苷二磷酸多聚酶抗原(N端)

hz-1201P PAX8(Paired box gene 8)  配对盒基因8抗原

hz-1102P PAX9(Paired box gene 9)  配对盒基因9抗原

hz-1159P P-cadherin(placental)  P-钙粘附分子抗原

hz-1617P LI-cadherin(liver-intestine cadherin)  肝肠钙粘连蛋白抗原

hz-1608P PDCD4(programmed cell death 4)  凋亡相关蛋白4抗原

hz-1333P TFAR19(TF-1 cell apoptsis-related gene 19)  凋亡相关蛋白TFAR19抗原

hz-2215P PCNA(phosphos Dyr211)peptide  磷酸化增殖细胞核多肽抗原

hz-1345P PCX/PODXL(Podocalyxin)  足细胞特异蛋白抗原

hz-1316P PDGF-BB peptide  血小板源性生长因子-BB抗原

hz-0923P Pdx1(pancreatic and duodenal homeobox 1)  胰十二指肠同源异型盒基因抗原

hz-2219P pectinesterase inhibitor 18 peptide  果胶酶抗原

hz-1084P PEG10(Paternally expressed gene 10)  肝癌高表达基因抗原

hz-2106P PENK/Enkephalin A(Preproencephalin A)  脑啡肽

hz-0584P PEPT2 (Peptide-transporters 2)  肠道肽转运蛋白2/小肽转运蛋白2抗原

hz-2469P PERK(PRKR-like endoplasmic reticulum kinase)  蛋白激酶R样内质网激酶抗原

hz-0796P FSCN1 (Fascin 1 protein; fascin homolog 1, actin-bundling protein)  纤维束蛋白同源物1/肌动蛋白集束蛋白/圆线虫紫癜 抗原

hz-0563P P-GP(P-glycoprotein)  P-糖蛋白抗原

hz-1551P Pepsinogen C peptide  胃蛋白酶原C蛋白抗原

hz-1832P PGC-1 Alpha(peroxisome proliferator-activated receptor- Gamma coactivator 1 Alpha)  过氧化物酶体增殖物激活受体γ辅激活子1α抗原

hz-0823P PGRN (progranulin)  颗粒蛋白前体抗原

hz-1449P PHB(Prohibitin)  抑制素/肿瘤抑制因子抗原

hz-0520P PKA(Protein Kinase A)  蛋白激酶A(多肽)

hz-1098P PLAU/uPA (Plasminogen activator,urokinase)  尿激酶型纤溶酶原激活因子（多肽）