多聚合苷酸激酶3磷酸化酶抗体

英文名称    DEM1    

中文名称    多聚合苷酸激酶3磷酸化酶抗体    

别    名    PNK1; Bifunctional polynucleotide phosphatase/kinase; DEM 1; DEM1; DNA 5' kinase/3' phosphatase; PNK 1; PNK; PNK1; PNKP; Polynucleotide 5' hydroxyl kinase; Polynucleotide kinase 3 prime phosphatase; Polynucleotide kinase 3' phosphatase; Polynucleotide Kinase; PNKP_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 多聚合苷酸激酶3磷酸化酶抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    57kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PNK1/PNKP    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

多聚合苷酸激酶3磷酸化酶抗体产品介绍    background:

Mammalian PNK catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. It plays an important function in DNA repair following ionizing radiation or oxidative damage. PNK has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.

Function:
Plays a key role in the repair of DNA damage,functioning as part of both the non-homologous end-joining (NHEJ)and base excision repair (BER) pathways. Through its two catalyticactivities, PNK ensures that DNA termini are compatible withextension and ligation by either removing 3'-phosphates from, or byphosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNAbackbone.    

多聚合苷酸激酶3磷酸化酶抗体公司更多热销抗体产品如下：

hz-1880R PTGEs  前列腺素E合成酶抗体

hz-1107R PTHrP/PTHLH  甲状旁腺激素相关蛋白抗体

hz-2444R PTN/Pleiotrophin  多效生长因子抗体

hz-2567R PTP/PTPase/CD148  蛋白酪氨酸磷酸酶CD148抗体

hz-4154R PTPRA  酪氨酸磷酸酶α抗体

hz-0182R PTP1B  蛋白酪氨酸磷酸酶-1B

hz-5103R MOSP/PTPMT1  线粒体蛋白酪氨酸磷酸酶1抗体

hz-1299R Parvalbumin  细小清蛋白抗体

hz-1881R Securin/PTTG  垂体肿瘤转化基因抗体

hz-2334R PXR  孤儿核受体PAR1抗体

hz-2364R PITX3  炎症因子3抗体（穿透素）

hz-5011R PYGL  肝糖原磷酸化酶抗体

hz-5012R PYGM  肌肉糖原磷酸化酶抗体

hz-2265R Peptide YY/PYY  酪酪肽抗体

hz-3556R Rad17/RFC  细胞周期检控Rad17蛋白抗体（复制因子C）

hz-3370R Phospho-Rad17 (Ser645)  磷酸化细胞周期检控Rad17蛋白抗体

hz-3868R Rab24  ras基因相关蛋白Rab24抗体

hz-5690R phospho-Rab24(Ser95)  磷酸化ras基因相关蛋白Rab24抗体

hz-5691R phospho-Rab24(Tyr17)  磷酸化ras基因相关蛋白Rab24抗体

hz-1221R Rad51  Rad51抗体

hz-1878R Rad52  Rad52抗体

hz-5684R phospho-RAD51(Tyr315)  磷酸化Rad51抗体

hz-2186R RAD51C  乳腺癌和卵巢癌易感基因RAD51C抗体

hz-3791R RAE1  mRNA结合蛋白抗体

hz-3808R Radixin  根蛋白抗体

hz-3559R Raptor  mTOR相关调控蛋白抗体

hz-3381R Phospho-Raptor (Ser792)  磷酸化mTOR相关调控蛋白抗体

hz-1504R RAP1A  抗Rap1A抗体

hz-5106R ALDH1  乙醛脱氢酶1型抗体

hz-5110R ALDH2/ALDHI  乙醛脱氢酶2抗体