英文名称 Phospho-BLNK (Tyr96)
中文名称 磷酸化T淋巴细胞连接蛋白抗体
别 名 BLNK (phospho Y96); p-BLNK (phospho Y96); B cell adapter containing SH2 domain protein; B cell adapter containing Src homology 2 domain protein; B cell linker; B cell linker protein; B cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; BASH; BASH; Bca; Bca; BLNK; BLNK s; BLNK_HUMAN; Cytoplasmic adapter protein; Ly 57; Ly-57; Ly57; Lymphocyte antigen 57; Lymphocyte antigen-57; Lyw 57; Lyw-57; Lyw57; MGC111051; SLP 65; SLP65; SLP-65; Src homology 2 domain containing leukocyte protein of 65 kDa.
说 明 书 0.1ml
产品类型 磷酸化抗体
磷酸化T淋巴细胞连接蛋白抗体研究领域 肿瘤 免疫学 信号转导 细胞凋亡 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human BLNK around the phosphorylation site of Tyr96 [DS(p-Y)EP]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磷酸化T淋巴细胞连接蛋白抗体产品介绍 background:
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
Function:
Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
磷酸化T淋巴细胞连接蛋白抗体公司更多热销抗体产品如下:
hz-3963R PKA R2/PKA IIα 蛋白激酶A受体2α亚基抗体
hz-4022R phospho-PKA R2 (Ser96) 磷酸化蛋白激酶A受体2α亚基抗体
hz-3965R PKA regulatory subunit I beta 蛋白激酶受体相关1β抗体
hz-0115M PKB/AKT-1 蛋白激酶B
hz-3969R PRKAR1 蛋白激酶A调节亚基a1抗体
hz-3643R PLASTIN3/T Plastin 丝束蛋白T Plastin抗体
hz-3807R PLAP/Phospholipase A2 activator protein 磷脂酶A2激活蛋白抗体
hz-3534R PLC beta 3 磷酯酶Cβ3抗体
hz-3340R Phospho-PLC beta3 (Ser537) 磷酸化磷酯酶Cβ3抗体
hz-3341R Phospho-PLC beta3 (Ser1105) 磷酸化磷酯酶Cβ3抗体
hz-0267R PKC beta 1/2 蛋白激酶C beta 1/2抗体
hz-2505R phospho-PRKCZ(Thr500) 磷酸化蛋白激酶C(T500)抗体
hz-2718R phospho-PKC beta 1/2(Thr500) 磷酸化蛋白激酶C β1/β2(Thr500)抗体
hz-3333R Phospho-PKC alpha/beta II (Thr638/641) 磷酸化蛋白激酶C α/β2抗体
hz-3531R PKC alpha 蛋白激酶C α抗体
hz-3532R PLCG 2/PLC gamma 2 磷酯酶Cγ2抗体
hz-3338R Phospho-PLCG2(Tyr1217) 磷酸化磷酯酶Cγ2抗体
hz-3339R Phospho-PLC gamma 2 (Tyr759) 磷酸化磷酯酶Cγ2抗体
hz-3533R PLCG 1/PLC gamma 1 磷酯酶Cγ1抗体
hz-5547R Phospho-PLC gamma 2(Tyr753) 磷酸化磷酯酶Cγ2抗体
hz-3460R Phospho-PLC gamma 1 (Tyr771) 磷酸化磷酯酶Cγ1抗体
hz-3342R Phospho-PLC gamma 1(Ser1248) 磷酸化磷酯酶Cγ1抗体
hz-3343R Phospho-PLC γ1 (Tyr783) 磷酸化磷酯酶Cγ1抗体
hz-5546R Phospho-PLC gamma 1/PLCG1(Tyr775) 磷酸化磷酯酶Cγ1抗体
hz-5560R phospho-PRKCZ(Thr410) 磷酸化蛋白激酶C(T410)抗体
hz-2329R PKC epsilon 蛋白激酶C抗体
hz-3626R PKC-γ/SCA14 蛋白激酶C亚型G抗体
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