英文名称 Beclin 1
中文名称 Bcl-2同源结构域蛋白抗体
别 名 Beclin 1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.
说 明 书 0.1ml 0.2ml 1ml
研究领域 肿瘤 免疫学 神经生物学 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 Bcl-2同源结构域蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human BECN1 (236-280aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Bcl-2同源结构域蛋白抗体产品介绍 background:
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.
Function:
Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
Bcl-2同源结构域蛋白抗体公司更多热销抗体产品如下:
hz-1156R NFKBIB/IKB beta 核因子κB抑制蛋白β抗体
hz-3191R Phospho-NFKBIB (Ser23) 磷酸化KB抑制蛋白β抗体
hz-1287R NFKBIA/IKB alpha 核因子κB抑制蛋白α抗体
hz-3229R IKKα(Phospho-Thr23) 磷酸化KB抑制蛋白激酶α抗体
hz-3234R phospho-IKK alpha (Tyr463) 磷酸化KB抑制蛋白激酶α抗体
hz-3235R phospho-IKK alpha (Ser176 + Ser180) 磷酸化KB抑制蛋白激酶α抗体
hz-3236R Phospho-IKK alpha/IKK beta (Ser180/Ser181) 磷酸化KB抑制蛋白激酶α/β抗体
hz-3237R Phospho-IKK alpha/beta (Ser176/Ser180) 磷酸化KB抑制蛋白激酶α/β抗体
hz-2513R phospho-NFKBIA(Ser32/36) 磷酸化IKB alpha(Ser32/36)抗体
hz-3233R phospho-IKK beta(Tyr188) 磷酸化KB抑制蛋白激酶β抗体
hz-3231R phospho-IKK beta(Ser466) 磷酸化KB抑制蛋白激酶β抗体
hz-3232R phospho-IKK beta(Tyr199) 磷酸化KB抑制蛋白激酶β抗体
hz-5514R Phospho-NFKBIA (Tyr42) 磷酸化IKB α抗体
hz-5398R phospho-IKK beta(Ser471) 磷酸化KB抑制蛋白激酶β抗体
hz-5399R phospho-IKK beta(Ser740) 磷酸化KB抑制蛋白激酶β抗体
hz-5515R phospho-NFKBIA(Tyr305) 磷酸化IKB alpha抗体
hz-5440R phospho-IKK beta(Ser733) 磷酸化KB抑制蛋白激酶β抗体
hz-5441R phospho-IKK beta(S474) 磷酸化KB抑制蛋白激酶β抗体
hz-5442R phospho-IKK beta(Ser476) 磷酸化KB抑制蛋白激酶β抗体
hz-3227R phospho-IKK gamma (Ser85) 磷酸化KB抑制蛋白激酶γ抗体
hz-3228R phospho-IKK gamma (Ser31) 磷酸化KB抑制蛋白激酶γ抗体
hz-3230R phospho-IKK gamma (Ser376) 磷酸化KB抑制蛋白激酶γ抗体
hz-5393R phospho-IKK gamma(Ser43) 磷酸化KB抑制蛋白激酶γ抗体
hz-4114R IKBKE/IKKi 核因子κB抑制蛋白E抗体
hz-5454R phospho-IKBKE(Thr501) 磷酸化核因子κB抑制蛋白E抗体
hz-5517R phospho-NFKBIE (Ser157) 磷酸化KB抑制蛋白激酶ε
hz-0245R IKI3 family protein 拟南芥IKI3抗体
hz-2428R IL-9 白介素9抗体
hz-0698R IL-10 白细胞介素-10抗体
hz-1827R IL-11 白介素11抗体
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