英文名称 ADAM13
中文名称 去整合素样金属蛋白酶13抗体
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 神经生物学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Xenopus (Silurana) tropicalis
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa 去整合素样金属蛋白酶13抗体
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Xenopus (Silurana) tropicalis ADAM13
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
去整合素样金属蛋白酶13抗体产品介绍 background:
ADAM13 was first described as a protein expressed in somatic mesoderm and neural crest cells, in developing Xenopus embryos. ADAM13 was also found in liver, heart, and intestines from adult Xenopus. ADAM13 may regulate cellular signaling via Src and Src tyrosine kinase. ADAM13 may also act as a cell attachment molecule, by binding integrins through the cysteine rich domain amoung many other roles. A member of the metalloproteinase family containing disintegrin like domains (ADAMs) the functions of ADAM13 are still poorly understood. ADAM13 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, as well as disintegrin, cysteine rich, EFG like, transmembrane and Cytoplasmic domains. ADAM13 has been shown to be proteolytically active, cleaving fibronectin after binding it to the EGF like domain. ADAM13 is also shed from cells in culture, cleaved aminoterminal from the transmembrane domain, and is released into the culture media. Shed ADAM13 is a 52 kD protein, and can form complexes with a2 macroglobulin, suggesting it is a competent protease. Xenopus ADAM13 has greatest homology with human ADAM 33 (51% identical), and is 46% identical with human or mouse ADAM12 or ADAM19. It is still unclear if any of these ADAMs are species orthologs of Xenopus ADAM13, but there are significant differences between the related sequences, suggesting that ADAM13 may be a unique protein. The full length Xenopus ADAM13 sequence codes for a 914 amino acid protein. Predicted mass is 99.749 kD, but glycosylation and cyteine rich regions give Xenopus ADAM13 an apparent MW of 120 kD unprocessed, and 97 kD processed forms, on reduced SDS PAGE gels. ADAM13 contains a putative furin cleavage site, suggesting that a prohormone convertase cleaves the propeptide domain away from the catalytic domain
去整合素样金属蛋白酶13抗体公司更多热销抗体产品如下:
hz-5522R phospho-NDEL1(Ser231) 磷酸化中心粒蛋白Nudel抗体
hz-5523R phospho-NDEL1(Ser242) 磷酸化中心粒蛋白Nudel抗体
hz-5524R phospho-NDEL1(Thr219) 磷酸化中心粒蛋白Nudel抗体
hz-1383R CD13/APN/ANPEN CD13氨肽酶N抗体
hz-1192R CD14 内毒素受体抗体
hz-2491R CD27/TNFRSF7 CD27抗体
hz-1297R CD28 CD28抗体
hz-0878R CD144/VECD/VE Cadherin 上皮型钙粘附分子抗体
hz-4142R NPTX1 神经细胞正五聚体1抗体
hz-5527R phospho-NPTX1(Tyr344) 磷酸化神经细胞正五聚体1抗体
hz-0684R CD147/TCSF/hzmprin 细胞外基质金属蛋白酶诱导因子抗体
hz-2526R CD160/By55 NK细胞受体BY55抗体
hz-2807R CD161 CD161抗体
hz-4682R CD161c/NK1.1 CD161抗体
hz-2527R CD163/M130 CD163抗体
hz-1251R CD166 活化白细胞粘附分子抗体
hz-2419R CD158a/KIR2DL1 NK细胞抑制性受体2DL1抗体
hz-2421R CD158e NK细胞抑制性受体3DL1抗体
hz-2642R CD158b2 NK细胞抑制性受体2DL3抗体
hz-2643R CD158 NK细胞抑制性受体2DL4抗体
hz-2644R CD158i NK细胞抑制性受体2DS4抗体
hz-2645R CD158e NK细胞抑制性受体3DL1抗体
hz-0671R MCK10/CD167a/DDR1 神经上皮酪氨酸激酶抗体(乳腺癌激酶10)
hz-4194R CD167b/DDR2 盘状结构域受体蛋白2抗体
hz-3845R CD168/RHAMM 透明质酸介导细胞游走受体抗体
hz-0794R CD169/sialoadhesin 唾液酸结合性免疫球蛋白样凝集素1抗体
hz-2703R CD170/Siglec-5 唾液酸结合性免疫球蛋白样凝集素5抗体
去整合素样金属蛋白酶13抗体 信息由上海沪震生物科技有限公司为您提供,如您想了解更多关于去整合素样金属蛋白酶13抗体 报价、型号、参数等信息,欢迎来电或留言咨询。除供应去整合素样金属蛋白酶13抗体 外,上海沪震生物科技有限公司还可为您提供BRCA1 (Ab-1524) 抗体、cdc25C (Ab-216) 抗体、SEK1/MKK4 (Ab-80) 抗体等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。