载脂蛋白B-mRNA编辑酶复合物3C抗体

英文名称    APOBEC3C    

中文名称    载脂蛋白B-mRNA编辑酶复合物3C抗体    

别    名    ABC3C_HUMAN; APOBEC1 like; APOBEC1-like; APOBEC1L; APOBEC3C; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; MGC19485; PBI; Phorbolin I; Phorbolin I protein; Probable DNA dC dU editing enzyme APOBEC 3C; Probable DNA dC->dU-editing enzyme APOBEC-3C.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 载脂蛋白B-mRNA编辑酶复合物3C抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human APOBEC3C    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

载脂蛋白B-mRNA编辑酶复合物3C抗体产品介绍    background:

APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.

Function:
Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.    

载脂蛋白B-mRNA编辑酶复合物3C抗体公司更多热销抗体产品如下：

hz-0954R ET-1  内皮素-1抗体

hzm-0954M ET-1(2C4)  内皮素-1单克隆抗体

hz-4198R ETBR/Endothelin B Receptor  内皮素B受体抗体

hz-3937R ETFB  电子转移黄素蛋白β肽/黄素蛋白抗体

hz-5897R ET-3  内皮素3抗体

hz-1285R Ets1/ETS-1  Ets转录因子家族ets1抗体

hz-2765R ETK/BMX  非受体性蛋白酪氨酸激酶ETK抗体

hz-3132R Phospho-BMX/ETK (Tyr40)  磷酸化非受体性蛋白酪氨酸激酶ETK抗体

hz-5223R Phospho-BMX/ETK (Tyr556)  磷酸化非受体性蛋白酪氨酸激酶ETK抗体

hz-5908R hzAP2  内皮单核细胞激活肽2抗体

hz-0613R Eukaryotic aspartyl protease  天冬氨酸蛋白酶家族蛋白抗体

hz-0852R EV71 polyprotein VP4  肠道病毒71型/手足口病病毒抗体

hz-5909R DeltaD/DLD  DeltaD抗体

hz-0983R EV71 polyprotein 3D  肠道病毒71型/手足口病病毒抗体

hz-0243R EXPB-2  植物延展素-β

hz-5910R DHH  DHH蛋白抗体

hz-2221R ATEXPA10  植物延长蛋白（拟南芥）

hz-1343R Ezrin  埃兹蛋白抗体

hz-3133R Phospho-Ezrin (Tyr353)  磷酸化埃兹蛋白抗体

hz-3134R Phospho-Ezrin (Thr567)  磷酸化埃兹蛋白抗体

hz-0949R F1 operon positive regulatory protein(NT)  肺鼠疫耶尔森氏菌F1荚膜蛋白抗体（N端）

hz-0950R F1 operon positive regulatory protein  肺鼠疫耶尔森氏菌F1荚膜蛋白抗体（C端）

hz-5104R FAAH1  脂肪酸酰胺水解酶1抗体

hz-5119R FAAH2  脂肪酸酰胺水解酶2抗体

hz-0788R intestinal FABP/IFABP  肠型脂肪酸结合蛋白抗体

hz-0386R FABP7/FABP(brain) CT  脑型脂肪酸结合蛋白抗体(C端)

hz-4059R FABP4  脂肪细胞型脂肪酸结合蛋白

hz-2370R FABP5  脂肪酸结合蛋白5抗体（上皮细胞型）

hz-2135R FABPB  脑型脂肪酸结合蛋白抗体