英文名称 APC10
中文名称 细胞周期后期促进蛋白亚基10抗体
别 名 ANAPC 10; anapc10; Anaphase promoting complex 10; Anaphase promoting complex subunit 10; Anaphase-promoting complex subunit 10; Apc 10; APC10; APC10_HUMAN; Cyclosome subunit 10; DKFZP564L0562; Doc 1; Doc1; OTTHUMP00000220297; OTTHUMP00000220298; OTTHUMP00000220299; OTTHUMP00000220300; OTTHUMP00000220303.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 细胞周期蛋白 泛素
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 细胞周期后期促进蛋白亚基10抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APC10
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
细胞周期后期促进蛋白亚基10抗体产品介绍 background:
Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
细胞周期后期促进蛋白亚基10抗体公司更多热销抗体产品如下:
hz-2565R DEC-205/CD205/Ly75 淋巴细胞抗原75抗体
hz-5056R DECR1 线粒体2,4-双烯酰辅酶A还原酶1抗体
hz-5843R PCDHB11 原钙粘蛋白β11抗体
hz-4057R DEGS1 退行性精母细胞同源物1抗体
hz-1037R DCP 异常凝血酶原/脱-γ-羧基凝血酶原抗体
hz-5828R PCDHB13 原钙粘蛋白13抗体
hz-5057R DHCR7 7脱氢胆固醇还原酶抗体
hz-1269R Doublecortin 双皮质素抗体
hz-3113R Phospho-Doublecortin (Ser297) 磷酸化双皮质素抗体
hz-2083R DcR1 肿瘤坏死因子配体超家族成员10C
hz-1694R DcR2/CD264/TNFRSF10D 诱捕受体2抗体
hz-2493R TNFRSF12A/TWEAKR/CD266 肿瘤坏死因子配体超家族成员12A抗体
hz-1716R DcR3/TR6 诱捕受体3抗体
hz-2785R DDAH-II 双甲基精氨酸水解酶2抗体
hz-3764R DDX19B/DBP5 解旋酶DEAD5抗体
hz-3514R D-DIMER 交联纤维蛋白二聚体抗体
hz-0993R DDX58 DDX58抗体
hz-5299R phospho-DDX58 (Ser8) 磷酸化DDX58抗体
hz-5300R phospho-DDX58 (Thr170) 磷酸化DDX58抗体
hz-2588R DDB1 DNA损伤结合蛋白1抗体
hz-2599R DDB2 DNA损伤结合蛋白2抗体
hz-0180R DDC/DOPA Decarboxylase 多巴胺脱羧酶抗体
hz-5829R NG2 硫酸软骨素蛋白多糖4/黑色素瘤相关蛋白抗体
hz-3597R DDX4/MVH DDX4抗体
hz-1697R DEF1/α Defensin 1/3 防御素α1/3抗体
hz-2799R Defensin alpha 4 防御素α4抗体
hz-1163R Defensin β1 防御素β1抗体
hz-5830R RAB21 G蛋白家族RAB21蛋白抗体
hz-2165R Defensin β1 防御素β1抗体
更多
企业名称
上海沪震生物科技有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2014-05-08
注册资本
1000
经营范围
上海沪震生物科技有限公司
公司地址
上海市杨浦区密云路1018号复旦科技园808室
客服电话