磷酸化腺瘤样息肉抗体

英文名称    phospho-APC (Ser2054)    

中文名称    磷酸化腺瘤样息肉抗体    

别    名    APC (phospho S2054); p-APC (phospho S2054); Adenomatous Polyposis Coli; APC; CC1; DP2; DP2.5; DP3; FAP; FPC; GS; Protein APC.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  发育生物学  神经生物学  信号转导  干细胞  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 磷酸化腺瘤样息肉抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    312kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human APC around the phosphorylation site of Ser2054    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化腺瘤样息肉抗体产品介绍    background:

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Subcellular Location:
Cell junction > adherens junction. Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.    

磷酸化腺瘤样息肉抗体公司更多热销抗体产品如下：

hz-4099R DAAM1  形态发生紊乱关联激活因子1抗体

hz-5303R phospho-DAAM1 (Thr361)  磷酸化形态发生紊乱关联激活因子1抗体

hz-3114R Phospho-Dab1 (Tyr220)  磷酸化Disabled 1抗体

hz-3115R Phospho-Dab1 (Tyr232)  磷酸化Disabled 1抗体

hz-3116R Phospho-Dab1 (Ser491)  磷酸化Disabled 1抗体

hz-3659R DACH2  转录调节因子DACH2抗体

hz-2762R DARPP32  多巴胺、cAMP调节磷蛋白抗体

hz-3118R Phospho-DARPP32(Thr34)  磷酸化多巴胺/cAMP调节神经磷蛋白抗体

hz-3119R Phospho-DARPP32(Thr75)  磷酸化多巴胺/cAMP调节磷蛋白抗体

hz-2332R DGAT1/Diglyceride acyltransferase  二脂酰甘油酰基转移酶抗体

hz-1007R DRD1  多巴胺受体D1抗体

hz-5825R PCDHA12  原钙粘蛋白12抗体

hz-5826R PCDHAC1  原钙粘蛋白1抗体

hz-1008R DRD2  多巴胺受体D2抗体

hz-1743R DRD3  多巴胺受体D3抗体

hz-1714R DAT/Dopamine transporter  多巴胺转运蛋白DAT抗体

hz-1746R DRD4  多巴胺受体D4抗体

hz-1747R DRD5/Dopamine receptor 5  多巴胺受体D5抗体

hz-2761R DBC1/deleted in bladder cancer 1  膀胱癌缺失基因1

hz-3117R Phospho-DBC1 (Thr454)  磷酸化膀胱癌缺失基因1抗体

hz-0596R DBH  多巴胺β羟化酶抗体

hz-5827R PCDHGB5  原钙粘蛋白γB5抗体

hz-3674R PBR/DBI/TSPO  外周苯二氮受体抗体

hz-0592R DCC  结肠直肠癌缺失基因抗体

hz-2564R DCIR/CLEC4A  C型凝集素结构域家族4成员A抗体

hz-1695R DCN/Decorin   核心蛋白聚糖抗体

hz-2663R CLEC5A/MDL1  C型凝集素结构域家族5成员A抗体

hz-2556R LAMP-3/DC-LAMP/CD208  溶酶体相关膜蛋白3抗体

hz-2557R DC-SIGN/CD209  细胞间粘附分子非整合素蛋白3抗体

hz-2239R DC-SIGN/CD209  细胞间粘附分子非整合素蛋白3抗体

hz-2563R DC-SIGNR/CD299  CD299抗体