英文名称 ACCN2
中文名称 脑钠通道蛋白2抗体
别 名 ASIC1; ACCN2; ACCN2_HUMAN; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; Acid-sensing ion channel 1; AI843610; Amiloride sensitive cation channel 2 neuronal; Amiloride-sensitive cation channel 2; ASIC; ASIC1; ASIC1A; B530003N02Rik; BNAC2; Brain sodium channel 2; Cation channel amiloride sensitive neuronal 2; hBNaC2; neuronal.
说 明 书 0.1ml 0.2ml
研究领域 神经生物学 通道蛋白 细胞膜受体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 脑钠通道蛋白2抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ACCN2/ASIC1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
脑钠通道蛋白2抗体产品介绍 background:
Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.
Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
脑钠通道蛋白2抗体公司更多热销抗体产品如下:
hz-6440R ZnT-1 锌转运蛋白1抗体
hz-6441R NPD014 1号染色体开放阅读框63抗体
hz-6442R RBP/Retinol binding protein 视黄醇结合蛋白抗体
hz-6443R PMCA1 细胞膜钙ATP酶1抗体
hz-6444R CDH11/OB-Cadherin 钙粘附蛋白-11抗体
hz-6446R Lin-28B RNA结合蛋白LIN28B抗体
hz-6447R HSP1/Protamine P1 精子鱼精蛋白P1抗体
hz-6448R EGR3 早期生长反应蛋白3抗体
hz-6449R SOX10 转录因子SOX10抗体
hz-6450R PMCA4/Calcium Pump PMCA4 ATPase 细胞膜钙ATP酶4抗体
hz-6451R phospho-ER-beta(ser105) 磷酸化雌激素受体β抗体
hz-6454R MFGE8/BA46 乳腺上皮细胞抗原BA46抗体
hz-6455R CHRNA3/AChRα3 烟碱型乙酰胆碱受体α3抗体
hz-6456R PEN2 早老素γ分泌酶2抗体
hz-6457R IGF-IRβ 胰岛素样生长因子1受体β抗体
hz-6458R HARS 组氨酸tRNA连接酶抗体
hz-6459R HNRPC 异质性核糖核蛋白C1/C2抗体
hz-6460R Mycobacterium human 人结核杆菌菌体蛋白抗体
hz-6461R NF-ATc4 T细胞激活核转录因子4抗体
hz-6462R Unc18-3 突触囊泡融合蛋白Unc18-3抗体
hz-6463R caspase-8 subunit p18 半胱氨酸蛋白酶8抗体
hz-6464R IRAK1 白介素-1受体相关激酶1抗体
hz-6465R phospho-APE(Ser1417) 磷酸化肌动蛋白结合蛋白Girdin抗体
hz-6466R PRDM1/Blimp1 B淋巴细胞诱导成熟蛋白1抗体
hz-6467R Dlx1 同源转录因子DLX1抗体
hz-6468R kir 6.1/IRK8 ATP敏感钾离子通道蛋白抗体
hz-6470R CLCN2/CLC-2 氯离子通道蛋白2抗体
hz-6471R ITPR3 5-三磷酸肌醇受体3抗体
hz-6472R PLC β2/Phospholipase C beta 2 磷酯酶Cβ2抗体
hz-6473R MUSK 肌肉骨骼受体酪氨酸激酶抗体
hz-6474R connexin-30 间隙连接蛋白30抗体
hz-6475R SGK3 丝氨酸/苏氨酸蛋白激酶Sgk3抗体
hz-6476R BAZ/ACF1 溴区结构域相邻锌指蛋白1A抗体
hz-6477R FAS/Apo-1/CD95 载脂蛋白1抗体
脑钠通道蛋白2抗体 信息由上海沪震生物科技有限公司为您提供,如您想了解更多关于脑钠通道蛋白2抗体 报价、型号、参数等信息,欢迎来电或留言咨询。除供应脑钠通道蛋白2抗体 外,上海沪震生物科技有限公司还可为您提供IKK α (Ab-23) 抗体、Histone H3.1 (Ab-10) 抗体、p21Cip1 (Ab-145) 抗体等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。