β淀粉样前体蛋白结合蛋白3抗体

英文名称    Mint3    

中文名称    β淀粉样前体蛋白结合蛋白3抗体    

别    名    Adapter protein X11gamma; amyloid beta (A4) precursor protein binding, family A, member 3; Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein; APBA3; lin 10; MGC:15815; Mint 3; Mint3; Mint-3; Neuron specific X11L2 protein; Neuronal Munc18 1 interacting protein 3; phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 like 2 protein 2; X11gamma; X11L2; APBA3_RAT.    

说 明 书    0.2ml      

研究领域    免疫学  神经生物学  细胞粘附分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 β淀粉样前体蛋白结合蛋白3抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    63kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from Rat Mint3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

β淀粉样前体蛋白结合蛋白3抗体产品介绍    background:

The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3).

Function:
May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).    

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