红细胞蛋白Ank1抗体

英文名称    Ankyrin erythroid    

中文名称    红细胞蛋白Ank1抗体    

别    名    ANK; ANK-1; Ank1; ANK1_HUMAN; Ankyrin 1; Ankyrin 1, erythrocytic; Ankyrin R; Ankyrin-1; Ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2.    

说 明 书    0.2ml      

研究领域    心血管  细胞生物  免疫学  信号转导  细胞粘附分子  细胞外基质      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 红细胞蛋白Ank1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    206kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Ankyrin erythroid    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

红细胞蛋白Ank1抗体产品介绍    background:

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008].

Function:
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. 
Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.     

红细胞蛋白Ank1抗体公司更多热销抗体产品如下：

hz-1171 NT-3(Mouse Neurotrophin 3) ELISA kit  小鼠神经生长因子3

hz-1171 OVA sIgE ELISA Kit  大鼠卵清蛋白特异性IgE

hz-1171 CNTF(Human Ciliary Neurotrophic Factor) ELISA Kit  人睫状神经营养因子

hz-1172 CD30(Human Cluster of differentiation 30) ELISA Kit  人CD30分子

hz-1172 CNP ELISA Kit  大鼠C型钠尿肽

hz-1172 NT-4(Mouse Neurotrophin 4) ELISA kit  小鼠神经生长因子4

hz-1173 Alpha-GST ELISA Kit  大鼠α谷胱甘肽S转移酶

hz-1173 OPG(Mouse Osteoprotegerin) ELISA KIT  小鼠骨保护素

hz-1173 CXCR1(Human CXC-chhzokine receptor 1) ELISA Kit  人CXC趋化因子受体1

hz-1174 XCR1(Human XC-chhzokine receptor 1) ELISA Kit  人XC趋化因子受体1

hz-1174 BF(Mouse factor B) ELISA Kit  小鼠B因子

hz-1174 Hcy ELISA Kit  大鼠同型半胱氨酸

hz-1175 GR- Beta ELISA Kit  大鼠糖皮质激素受体β

hz-1175 SLC/CCL21(Human secondary lymphoid-tissue chhzokine) ELISA Kit  人二级淋巴组织趋化因子

hz-1175 OSM(Mouse Oncostatin-M) ELISA KIT  小鼠抑瘤素M

hz-1176 PDGFsR- Alpha(Mouse Platelet-Derived Growth Factor Soluble Receptor Alpha) ELISA kit  小鼠血小板衍生生长因子可溶性受体α

hz-1176 GR- Alpha ELISA Kit  大鼠糖皮质激素受体α

hz-1176 E-Cad(Human E-Cadherin) ELISA Kit  人E钙粘着蛋白/上皮性钙黏附蛋白

hz-1177 BDNF(Human Brain derived neurotrophic facor) ELISA Kit  人脑源性神经营养因子

hz-1177 Col IV ELISA KIT  大鼠Ⅳ型胶原

hz-1177 PDGF-AB(Mouse Platelet-Derived Growth Factor AB) ELISA kit  小鼠血小板衍生生长因子AB

hz-1178 P-Selectin/CD62P(Mouse P-Selectin) ELISA kit  小鼠P选择素

hz-1178 HK ELISA Kit  大鼠己糖激酶

hz-1178 ALCAM(Human Activated Leukocyte Cell Adhesion Molecule) ELISA Kit  人白细胞活化黏附因子

hz-1179 GSK ELISA Kit  大鼠糖原合成酶激酶

hz-1179 ACV-A(Human Activin A) ELISA Kit  人活化素A

hz-1179 PAL(Mouse L-Phenylalanine ammonla-lyase) ELISA Kit  小鼠L苯丙氨酸解氨酶