腺病毒早期E1A蛋白抗体

英文名称    Adenovirus 5 E1A    

中文名称    腺病毒早期E1A蛋白抗体    

别    名    Adenovirus early E1A protein; Control protein E1A; E1A; Early E1A protein; Human adenovirus type 5; Human adenovirus C; pfam02703; E1A_ADE05.    

说 明 书    0.2ml      

研究领域    免疫学  细菌及病毒      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    adenovirus5    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    32kDa    

腺病毒早期E1A蛋白抗体性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

腺病毒早期E1A蛋白抗体产品介绍    background:

The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.

Function:
E1A protein has both transforming and trans-activating activities. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Disrupts the function of host retinoblastoma protein RB1/pRb and isoform early E1A 26 kDa protein stabilizes TP53, which are key regulators of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.    

腺病毒早期E1A蛋白抗体公司更多热销抗体产品如下：

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hz-1184P TRAF6 (TNF receptor-associated factor 6)  肿瘤坏死因子受体相关因子6抗原

hz-1214P TRAIL/Apo2L (tumor necrosis factor-related apoptosis-inducing ligand)  肿瘤坏死因子相关凋亡诱导配体/凋亡素2配体抗原

hz-1151P TRBF1 (Telomeric repeat binding factor 1)  端粒体复制结合因子1抗原

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hz-1243P Trop-2/Tpm2 peptide  原肌球蛋白抗原

hz-1220P TSARG4(Testis and spermatogenesis related gene 4)  生精细胞凋亡相关基因4抗原

hz-0546P TSGF(Tumor Specific Growth Fanctor)  恶性肿瘤特异性生长因子抗原

hz-0716P CIDEB peptide  CIDEB抗原

hz-1365P Tsg101(Tumor susceptibility gene 101 protein)  Tsg101抗原

hz-2087P TSHR (Thyroid stimulating hormone receptor)  促甲状腺素受体抗原

hz-1534P MAP1LC3A(microtubule-associated protein 1 light chain 3)  自噬微管相关蛋白轻链3抗原

hz-1147P TSLC1 (tumor suppressor in lung cancer-1)  肺癌肿瘤阻抑基因1抗原

hz-0826P TTF-1 (Thyroid Transcription Factor-1)  甲状腺核转录因子-1抗原

hz-1322P Tubulin- Gamma  微管蛋白-γ抗原

hz-2441P TWIST protein peptide  TWIST蛋白抗原

hz-1088P T Beta10 peptide  胸腺素β10抗原

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hz-1403P USF-1(upstream stimulatory factor 1)  上游刺激因子1抗原

hz-1549P Ubiquitin  泛素蛋白

hz-1505P VASH1(Vasohibin 1)  兔抗血管抑制蛋白1抗原

hz-0396P VCAM-1/CD106(Vascular cell adhesion molecule 1 isoform b precusor; CD106 antigen)  血管内皮细胞粘附分子抗原

hz-0920P VCAM-1/CD106 (Vascuolar cell adhesion molecule 1)  血管内皮细胞粘附分子抗原