整合素样金属蛋白酶与凝血酶9型抗体

英文名称    ADAMTS9    

中文名称    整合素样金属蛋白酶与凝血酶9型抗体    

别    名    A disintegrin and metalloproteinase with thrombospondin motifs 9; ADAM TS 9; ADAM TS9; A disintegrin and metalloproteinase with thrombospondin motifs 9; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 9; A disintegrin like and metalloprotease with thrombospondin type 1 motif 9; ADAM metallopeptidase with thrombospondin type 1 motif 9; ADAM TS 9; ADAM TS9; ADAMTS 9; ADAMTS9; ADAMTS-9; ATS9_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞粘附分子  锌指蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500整合素样金属蛋白酶与凝血酶9型抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    181kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ADAMTS9    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

整合素样金属蛋白酶与凝血酶9型抗体产品介绍    background:

ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. ADAMTS9 is closest in homology to ADAMTS20, sharing 54% overall identity, and like ADAMTS20 ADAMTS9 gas a GON like domain at the carboxyterminal end. The GON domain at the carboxyterminal end is similar to the GON1 protein in C. elegans, mutations of which lead to defective gonadal development. ADAMTS9 is expressed in ovary and testis, but little is known about the role of ADAMTS9 in reproductive organs. ADAMTS9 is also expressed in the heart, placenta, lung, skeletal tissue, and pancreas, so the protein must have wider functions than just gonadal development. ADAMTS9, like ADAMTS20, has a total of 15 thrombospondin like domains. The first TS domain begins shortly after the catalytic and disintegrin domains. TS domains 2 to 6 follow a spacer domain, followed by linker domain 1, then TS domains 7 & 8, linker domain 2, and then TS domains 9 to 15. In other ADAMTS proteins the TS motifs are thought to bind to the ECM. The ADAMTS proteins contain at least one prohormone convertase cleavage site, although it appears that one site is used preferentially, and cleavage of the propeptide domain at this site generates active enzymes. For ADAMTS9, this site is the RRTKR sequence, and the mature ADAMTS9 has an aminoterminal sequence of FLSYPR. The catalytic site of ADAMTS9 is most like ADAMTS1, 14 and 15, with an HExxHVFNMxH sequence, perhaps giving these enzymes some shared specificity.

Function:
Cleaves the large aggregating proteoglycans, aggrecan and versican.    

整合素样金属蛋白酶与凝血酶9型抗体公司更多热销抗体产品如下：

hz-0019P OPN  骨桥蛋白（多肽抗原）

hz-2431P BAFF/CD257(B cell activating factor)  TNF家族B细胞激活因子抗原

hz-0033P P53  肿瘤抑制基因（抗原）

hz-0190P PACAP-27/38  腺苷酸环化酶激活肽-27/38（抗原）

hz-0200P PACAP-38  腺苷酸环化酶激活肽-38（抗原）

hz-1153P Bid (BH3 interacting domain death agonist)  BH3结构域凋亡诱导蛋白抗原

hz-2357P PACAP(6-38 Peptide)  腺苷酸环化酶激活肽6-38

hz-0197P PACAP/VIP receptor  腺苷酸环化酶激活肽/血管活性肠肽受体（抗原）

hz-0198P PACAP receptor-I  腺苷酸环化酶激活肽受体（抗原）

hz-0318P PADI4 (HL-60 PAD)(Protein-arginine deiminase type IV，PADI 4，PAD I4 )  关节炎相关基因

hz-0196P PDGF-A  血小板源性生长因子-1（抗原）

hz-0185P PDGF-B  血小板源性生长因子-B（抗原）

hz-0231P PDGF-R-A  血小板源性生长因子受体-A（抗原）

hz-0232P PDGF-R-B  血小板源性生长因子受体-B（抗原）

hz-0235P PMP-22(Peripheral Myelin Protein)  外周髓鞘蛋白-22多肽

hz-0128P PI3K  磷脂酰肌醇激酶（抗原）

hz-1374P BMP4(bone morphogenetic protein 4)  骨形态发生蛋白4（抗原）

hz-0234P PLGF (Placenta growth factor)  小鼠胎盘生长因子（多肽抗原）

hz-0280P PLGF (Placenta growth factor)  胎盘生长因子（多肽抗原）

hz-0281P PLGF (Placenta growth factor fragment)(human)  人胎盘生长因子（多肽抗原）

hz-0133P PP-1  蛋白磷酸酯酶-1（抗原）

hz-1509P BMPR-1A(Bone Morphogenetic protein Receptor-1A)  骨成型蛋白受体1A抗原

hz-0250P PPAR-delta (peroxisome proliferator-activated receptor)  D型-过氧化酶活化增生受体(多肽）

hz-0029P PP-2A (protein phosphatase 2A)  蛋白质磷酸酶-2A（抗原）

hz-1418P BOb-1(B-cell oct-binding protein 1)  B细胞特异性转录因子抗原

hz-0030P PP-2B alpha 1   蛋白磷酸酯酶-2B 催化亚单位（抗原）

hz-0111P PR (Progestogerone receptor)  孕激素受体（抗原）

hz-0024P PS-1(NT)，Presennillin-1(S182)  早老素蛋白-1（抗原）

hz-0025P PS-1，Presennillin-1(CT)  早老素蛋白-1（S182）

hz-0803P BRCA1(Breast cancer susceptbility gene 1)(mouse rat)  乳腺癌易感基因1抗原(小鼠 大鼠)