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磷酸化活化复制因子2抗体

供货周期: 现货
品牌: CST
规格: g/mg
货号: hz-1648R
CAS号:
报价: ¥1
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产品介绍

英文名称    phospho-ATF2 (Ser490/498)    

中文名称    磷酸化活化复制因子2抗体    

别    名    ATF2 (phospho S490); p-ATF2 (phospho S490); ATF2 (phospho S490 + S498); p-ATF2 (phospho S490 + S498); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域   磷酸化活化复制因子2抗体 肿瘤  免疫学  染色质和核信号  信号转导  细胞凋亡  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Rabbit, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    45kDa    

细胞定位    细胞核     

磷酸化活化复制因子2抗体性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Ser490/498    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

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磷酸化活化复制因子2抗体信息由上海沪震生物科技有限公司为您提供,如您想了解更多关于磷酸化活化复制因子2抗体报价、型号、参数等信息,欢迎来电或留言咨询。除供应磷酸化活化复制因子2抗体外,上海沪震生物科技有限公司还可为您提供AMPKα1 (Ab-487)抗体、PKD/PKCμ (Ab-738) 抗体、PLCγ1 (Ab-783) 抗体等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。
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磷酸化活化复制因子2抗体

磷酸化活化复制因子2抗体 Background: ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain. Also known as: ATF2 (phospho S490); p-ATF2 (phospho S490); ATF2 (phospho S490 + S498); p-ATF2 (phospho S490 + S498); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive.

23KB

2015/01/16

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