柔软培养基质或可促进诱导多能性干细胞的产生

此前研究者发现，柔软的基质可以影响培养细胞更新和繁殖的能力，本文中研究者通过研究检测是否相同的原理也可以应用到增强诱导多能干细胞（iPS）的产量研究上，iPS是一种可以将成熟的成体成纤维细胞利用特殊方法重编程而形成的一类干细胞。

HZC011Po ELISA Kit for Complement Factor B (CFB) 猪补体因子B(CFB)检测试剂盒

HZA119Po ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) 猪CD40配体(CD40L)检测试剂盒

HZA228Po ELISA Kit for Anti-Mullerian Hormone (AMH) 猪抗缪勒管激素(AMH)检测试剂盒

HZA072Po ELISA Kit for Defensin Beta 2 (DEFb2) 猪防御素β2(DEFβ2)检测试剂盒

HZA212Po ELISA Kit for Matrix Metalloproteinase 23B (MMP23B) 猪基质金属蛋白酶23B(MMP23B)检测试剂盒

HZA120Po ELISA Kit for Stem Cell Factor (SCF) 猪干细胞因子(SCF)检测试剂盒

HZA123Po ELISA Kit for Transforming Growth Factor Alpha (TGFa) 猪转化生长因子α(TGFα)检测试剂盒

HZA213Po ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 猪髓细胞触发受体1(TREM1)检测试剂盒

(TREM1)

HZA006Po ELISA Kit for Amphiregulin (AREG) 猪双调蛋白(AREG)检测试剂盒

HZA128Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 猪组织金属蛋白酶抑制因子2(TIMP2)检测试剂盒

(TIMP2)

HZA129Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 猪组织金属蛋白酶抑制因子3(TIMP3)检测试剂盒

(TIMP3)

HZA053Po ELISA Kit for Insulin Like Growth Factor Binding Protein 2 猪胰岛素样生长因子结合蛋白2(IGFBP2)检测试剂盒

(IGFBP2)

HZA214Po ELISA Kit for Caveolin 1 (CAV1) 猪窖蛋白(CAV1)检测试剂盒

HZA131Po ELISA Kit for Transforming Growth Factor Beta Induced Protein 猪转化生长因子β诱导蛋白(TGFβI)检测试剂盒

(TGFbI)

HZA130Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 4 猪组织金属蛋白酶抑制因子4(TIMP4)检测试剂盒

(TIMP4)

HZA134Po ELISA Kit for Tumor Necrosis Factor Beta (TNFb) 猪肿瘤坏死因子β(TNFβ)检测试剂盒

HZA055Po ELISA Kit for Insulin Like Growth Factor Binding Protein 4 猪胰岛素样生长因子结合蛋白4(IGFBP4)检测试剂盒

(IGFBP4)

HZA135Po ELISA Kit for Thrombopoietin (TPO) 猪血小板生成素(TPO)检测试剂盒

HZA140Po ELISA Kit for Plasminogen Activator, Urokinase (uPA) 猪尿激酶型纤溶酶原激活因子(uPA)检测试剂盒

HZA059Po ELISA Kit for Interleukin 12A (IL12A) 猪白介素12A(IL12A)检测试剂盒

HZA217Po ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) 猪α1-微球蛋白(α1M)检测试剂盒

HZA061Po ELISA Kit for Interleukin 15 (IL15) 猪白介素15(IL15)检测试剂盒

文章中，研究者利用一系列具有不同组分和弹性的凝胶基质检测其对培养小鼠和人类成纤维细胞的效果，结果显示，相比常规的坚硬塑料培养皿生长的细胞来讲，在柔软基质表面生长的细胞中和重编程干细胞相关的基因活性较强，同时研究者还发现培养细胞基质的改变可以明显改变肌动蛋白纤维的量以及分布情况，这就表明肌动蛋白也介导了重编程成体干细胞的过程。