上海交通大学医学院细胞分化和凋亡教育部重点实验室的研究人员发现,急性淋巴细胞白血病干细胞通过建造新的骨髓微环境逃避化疗。相关研究成果近日发表在《癌细胞》上。
据介绍,白血病的治疗主要依靠化疗,但化疗难以清除骨髓中的白血病干细胞,导致白血病容易复发。因此,回答化疗开始后骨髓中到底发生了什么?白血病干细胞如何逃避化疗等科学问题对研究治疗策略非常重要。
研究人员先将人急性淋巴细胞白血病细胞注入小鼠体内,建立白血病小鼠模型,之后给予化疗,用先进的成像技术等进行观察和研究。发现白血病细胞在骨髓中浸润性生长,在实质性破坏正常骨髓微环境后,给予化疗,白血病干细胞会分泌一些细胞因子,招募和改造骨髓间充质干细胞,建立一个临时的“庇护所”,逃避化疗杀伤。正如地震摧毁了房屋,幸存者搭建一个临时帐篷,度过灾难期。
研究者在骨髓里发现并鉴定了这个“临时帐篷”,并将这个新建的“庇护所”称为NSM 微环境。研究者发现,干扰NSM 微环境的形成或保护功能,可以明显提高化疗效果,清除骨髓中残留的白血病干细胞。同时,通过化疗不能缓解或部分缓解的白血病病人样本中,检测到这种微环境的标志物,在完全缓解的白血病人样本中却检测不到。
专家认为,该研究的意义在于:可以通过检测一种标志物来判断病人预后,并靶向干扰其形成或功能,从而提高化疗效果,甚至治愈白血病。同时,该研究也可能应用在其他肿瘤治疗中。
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人白介素1β (IL-1β)ELISA试剂盒 Human Interleukin 1β,IL-1β ELISA试剂盒
人表皮生长因子(EGF)ELISA试剂盒 Human Epidermal growth factor,EGF ELISA试剂盒
人碱性成纤维细胞生长因子(bFGF)ELISA试剂盒 Human basic fibroblast growth factor,bFGF ELISA试剂盒
人巨噬细胞炎性蛋白5(MIP-5)ELISA试剂盒 Human macrophage inflammatory protein 5,MIP-5 ELISA试剂盒
人可溶性E选择素(sE-selectin)ELISA试剂盒 Human soluble E-selectin,sE-selectin ELISA试剂盒
人可溶性细胞间粘附分子1(sICAM-1)ELISA试剂盒 Human Soluble Intercellular Adhesion Molecule-1,sICAM-1 ELISA试剂盒
人细胞间粘附分子2(ICAM-2/CD102)ELISA试剂盒 Human intercellular adhesion molecule 2,ICAM-2 ELISA试剂盒
人细胞间粘附分子3(ICAM-3/CD50)ELISA试剂盒 Human intercellular adhesion molecule 3,ICAM-3 ELISA试剂盒
人结缔组织生长因子(CTGF)ELISA试剂盒 Human connective tissue growth factor,CTGF ELISA试剂盒
人白介素18(IL-18)ELISA试剂盒 Human Interleukin 18,IL-18 ELISA试剂盒
人粘膜相关上皮趋化因子(MEC/CCL28)ELISA试剂盒 Human mucosae associated epithelia chemokine,MEC ELISA试剂盒
人粘膜相关上皮趋化因子(MEC/CCL28)ELISA试剂盒 Human mucosae associated epithelia chemokine,MEC ELISA试剂盒
人B细胞活化因子受体(BAFF-R)ELISA试剂盒 Human B cell activation factorr from the tumor necrosis factor family receptor,BAFF-R ELISA试剂盒
人血管内皮细胞生长因子受体3(VEGFR-3/Flt-4)ELISA试剂盒 Human Vascuoar endothelial cell growth factor receptor 2,VEGFR-2/Flk-1 ELISA试剂盒
人血管内皮细胞生长因子受体1(VEGFR-1/Flt1)ELISA试剂盒 Human Vascuoar endothelial cell growth factor receptor 1,VEGFR-1/Flt1 ELISA试剂盒
人血管内皮细胞生长因子D(VEGF-D)ELISA试剂盒 Human Vascular Endothelial cell Growth Factor D,VEGF-D ELISA试剂盒
人血管内皮细胞生长因子C(VEGF-C)ELISA试剂盒 Human Vascular Endothelial cell Growth Factor C,VEGF-C ELISA试剂盒
人血管内皮细胞生长因子D(VEGF-D)ELISA试剂盒 Human Vascular Endothelial cell Growth Factor D,VEGF-D ELISA试剂盒
人血管内皮细胞生长因子C(VEGF-C)ELISA试剂盒 Human Vascular Endothelial cell Growth Factor C,VEGF-C ELISA试剂盒
人血管内皮细胞生长因子B(VEGF-B)ELISA试剂盒 Human Vascular Endothelial cell Growth Factor B,VEGF-B ELISA试剂盒
人血管内皮细胞生长因子(VEGF)ELISA试剂盒 Human Vascular Endothelial cell Growth Factor,VEGF ELISA试剂盒
人血管内皮细胞粘附分子1(VCAM-1/CD106)ELISA试剂盒 Human Vascuolar cell adhesion molecule 1,VCAM-1 ELISA试剂盒
人可溶性肿瘤坏死因子相关凋亡诱导配体(sTRAIL)ELISA试剂盒 Human soluble tumor necrosis factor-related apoptosis inducing ligand,sTRAIL ELISA试剂盒
人肿瘤坏死因子相关凋亡诱导配体4(TRAIL-R4)ELISA试剂盒 Human tumor necrosis factor-related apoptosis-inducing ligand 4,TRAIL-R4 ELISA试剂盒
人肿瘤坏死因子相关凋亡诱导配体3(TRAIL-R3)ELISA试剂盒 Human tumor necrosis factor-related apoptosis-inducing ligand 3,TRAIL-R3 ELISA试剂盒
人肿瘤坏死因子相关凋亡诱导配体1(TRAIL-R1)ELISA试剂盒 Human tumor necrosis factor-related apoptosis-inducing ligand 1,TRAIL-R1 ELISA试剂盒
人肿瘤坏死因子β(TNF-β)ELISA试剂盒 Human Tumor necrosis factor β,TNF-β ELISA试剂盒
人肿瘤坏死因子α(TNF-α)ELISA试剂盒 Human Tumor necrosis factor α,TNF-α ELISA试剂盒
人肿瘤坏死因子可溶性受体Ⅱ(TNFsR-Ⅱ)ELISA试剂盒 Human Tumor necrosis factor soluble receptor Ⅱ,TNFsR-Ⅱ ELISA试剂盒
人肿瘤坏死因子可溶性受体Ⅰ(TNFsR-Ⅰ)ELISA试剂盒 Human Tumor necrosis factor soluble receptor Ⅰ,TNFsR-ⅠELISA试剂盒
人转化生长因子β1(TGF-β1)ELISA试剂盒 Human Transforming Growth factor β1,TGF-β1 ELISA试剂盒
人转化生长因子α(TGF-α)ELISA试剂盒 Human transforming growth factor α,TGF-α ELISA试剂盒
人基质细胞衍生因子1β(SDF-1β/CXCL12)ELISA试剂盒 Human Stromal cell derived factor 1β,SDF-1β ELISA试剂盒
人干细胞因子受体(SCFR)ELISA试剂盒 Human Stem Cell Factor Receptor,SCFR ELISA试剂盒
人干细胞因子/肥大细胞生长因子(SCF/MGF)ELISA试剂盒 Human Stem cell factor/mast cell growth factor,SCF/MGF ELISA试剂盒
人可溶性CD40配体(sCD40L)ELISA试剂盒 Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA试剂盒
人可溶性CD30配体(sCD30L)ELISA试剂盒 Human Soluble Cluster of differentiation 30 ligand,sCD30L ELISA试剂盒
人正常T细胞表达和分泌因子(RANTES/CCL5)ELISA试剂盒 Human regulated on activation in normal T-cell expressed and secreted,RANTES ELISA试剂盒
人P选择素(P-Selectin/CD62P/GMP140)ELISA试剂盒 Human P-Selectin/CD62P/GMP140 ELISA试剂盒
人血血小板衍生生长因子AB(PDGF-AB)ELISA试剂盒 Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA试剂盒
人血血小板衍生生长因子可溶性受体α(PDGFsR-α)ELISA试剂盒 Human Platelet-Derived Growth Factor Soluble Receptor α,PDGFsR-α ELISA试剂盒
人神经营养因子4(NT-4)ELISA试剂盒 Human Neurotrophin 4,NT-4 ELISA试剂盒
人神经营养因子3(NT-3)ELISA试剂盒 人神经营养因子3(NT-3)ELISA试剂盒
人的神经生长因子(NGF)ELISA试剂盒 Human Nerve growth factor,NGF ELISA试剂盒
人巨噬细胞炎性蛋白3β(MIP-3β/ELC/CCL19)ELISA试剂盒 Human Macrophage Inflammatory Protein-3β,MIP-3β ELISA试剂盒
人巨噬细胞炎性蛋白3α(MIP-3α/CCL20)ELISA试剂盒 Human Macrophage Inflammatory Protein-3α,MIP-3α ELISA试剂盒
人巨噬细胞炎性蛋白1β(MIP-1β/CCL4)ELISA试剂盒 Human Macrophage Inflammatory Protein-1β,MIP-1β ELISA试剂盒
人巨噬细胞炎性蛋白1α(MIP-1α/CCL3)ELISA试剂盒 Human Macrophage Inflammatory Protein-1α,MIP-1α ELISA试剂盒
人巨噬细胞来源的趋化因子(MDC/CCL22)ELISA试剂盒 Human Macrophage-Derived Chemokine,MDC ELISA试剂盒
人巨噬细胞来源的趋化因子(MDC/CCL22)ELISA试剂盒 Human Macrophage-Derived Chemokine,MDC ELISA试剂盒
人巨噬细胞集落刺激因子(M-CSF)ELISA试剂盒 Human Macrophage Colony-Stimulating Factor,M-CSF ELISA试剂盒
人单核细胞趋化蛋白3(MCP-3/CCL7)ELISA试剂盒 Human monocyte chemotactic protein 3,MCP-3 ELISA试剂盒
人单核细胞趋化蛋白2(MCP-2/CCL8)ELISA试剂盒 Human monocyte chemotactic protein 2,MCP-2 ELISA试剂盒
人单核细胞趋化蛋白1(MCP-1/CCL2/MCAF)ELISA试剂盒 Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA试剂盒
人L选择素(L-Selectin/CD62L)ELISA试剂盒 Human L-Selectin ELISA试剂盒
人白介素9(IL-9)ELISA试剂盒 Human Interleukin 9,IL-9 ELISA试剂盒
人白介素8(IL-8/CXCL8)ELISA试剂盒 Human Interleukin 8,IL-8 ELISA试剂盒
人白介素6(IL-6)ELISA试剂盒 Human Interleukin 6,IL-6 ELISA试剂盒
人白介素-5(IL-5)ELISA试剂盒 Human Interleukin 5,IL-5 ELISA试剂盒
人白介素4(IL-4)ELISA试剂盒 Human Interleukin 4,IL-4 ELISA试剂盒
人白介素3(IL-3)ELISA试剂盒 Human Interleukin 3,IL-3 ELISA试剂盒
人白介素2可溶性受体β链(IL-2sRβ )ELISA试剂盒 Human Interleukin 2,IL-2 ELISA试剂盒
人白介素2可溶性受体α链(IL-2sRα/CD25)ELISA试剂盒 Human soluble interleukin-2 receptor,IL-2sRα ELISA试剂盒
人白介素2(IL-2)ELISA试剂盒 Human Interleukin 2,IL-2 ELISA试剂盒
人白介素1α(IL-1α )ELISA试剂盒 Human Interleukin 1α,IL-1α ELISA试剂盒
人白介素1可溶性受体Ⅱ(IL-1sRⅡ)ELISA试剂盒 Human soluble interleukin-1 receptor Ⅱ,IL-1sRⅡ ELISA试剂盒
人白介素1可溶性受体Ⅰ(IL-1sRⅠ)ELISA试剂盒 Human soluble interleukin-1 receptor Ⅰ,IL-1sRⅠ ELISA试剂盒
人白介素16(IL-16)ELISA试剂盒 Human Interleukin 16,IL-16 ELISA试剂盒
人白介素13(IL-13)ELISA试剂盒 Human Interleukin 13,IL-13 ELISA试剂盒
人白介素12(IL-12/P70)ELISA试剂盒 Human Interleukin 12,IL-12/P70 ELISA试剂盒
人白介素12(IL-12/P40)ELISA试剂盒 Human Interleukin 12,IL-12/P40 ELISA试剂盒
人白介素11(IL-11)ELISA试剂盒 Human Interleukin 11,IL-11 ELISA试剂盒
人白介素10(IL-10)ELISA试剂盒 Human Interleukin 10,IL-10 ELISA试剂盒
人胰岛素样生长因子结合蛋白4(IGFBP-4)ELISA试剂盒 Human insulin-like growth factors binding protein 4,IGFBP-4 ELISA试剂盒
人胰岛素样生长因子结合蛋白3(IGFBP-3)ELISA试剂盒 Human insulin-like growth factors binding protein 3,IGFBP-3 ELISA试剂盒
人胰岛素样生长因子结合蛋白2(IGFBP2)ELISA试剂盒 Human insulin-like growth factors binding protein 2,IGFBP-2 ELISA试剂盒
人胰岛素样生长因子结合蛋白1(IGFBP-1)ELISA试剂盒 Human insulin-like growth factors binding protein 1,IGFBP-1 ELISA试剂盒
人胰岛素样生长因子2(IGF-2)ELISA试剂盒 Human insulin-like growth factors 2,IGF-2 ELISA试剂盒
人胰岛素样生长因子1(IGF-1)ELISA试剂盒 Human insulin-like growth factors 1,IGF-1 ELISA试剂盒
人γ干扰素(IFN-γ)ELISA试剂盒 Human Interferon γ ,IFN-γ ELISA试剂盒
人细胞间粘附分子1(ICAM-1/CD54)ELISA试剂盒 Human intercellular adhesion molecule 1,ICAM-1 ELISA试剂盒
人肝细胞生长因子(HGF)ELISA试剂盒 Human hepatocyte growth factor,HGF ELISA试剂盒
人粒细胞巨噬细胞集落刺激因子(GM-CSF)ELISA试剂盒 Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA试剂盒
人胶质细胞系来源的神经营养因子(GDNF)ELISA试剂盒 Human glial cell line-derived neurotrophic factor,GDNF ELISA试剂盒
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