Rat anti-guinea pig Interleukin-2

Rat anti-guinea pig Interleukin-2 Collect Sample – serum or blood plasma Package size: 96 determinations Catalogue No.: QRCT –652113EIA \ UTL Storage: 2 - 8 °C I. INTRODUCTION Interleukin-2 (IL-2) plays a critical role in the mediation of immune response by acting as a growth factor for T cells and natural killer cells as well as a growth and differentiation factor for B cells. The protein undergoes extensive post-translational modification including cleavage, glycosylation and the formation of disulfide bonds before it becomes biologically active. Portions of IL-2 are highly conserved across species boundaries in areas involved in receptor binding during activated complex formation. Two types of IL-2 receptor complexes have been identified as low affinity and high affinity receptors. Once bound by IL-2, cells expressing the receptors undergo activation, proliferation and functional differentiation. The only cell types known to produce IL-2 are T cells, large granular lymphocytes, and some pre-T cell and B cell tumors and cell lines. IL-2 causes the regression of a number of tumor and cancer cells, has antiviral and antibacterial applications and enhances autoimmunity and resistance to certain parasitic diseases. IL-2 administration can also cause rejection of stable tissue grafts.