goat anti –Rabbit Interleukin-6

goat anti –Rabbit Interleukin-6 Collect Sample – serum or blood plasma Package size: 96 determinations Catalogue No.: QRCT –561216EIA \ UTL Storage: 2 - 8 °C I. INTRODUCTION Interleukin 6 (IL-6) is a multifunctional protein produced by lymphoid and non-lymphoid cells, and by normal and transformed cells, including T cells, monocyte/macrophages, fibroblasts, hepatocytes, vascular endothelial cells, cardiac myxomas, bladder cell carcinomas, myelomas, astrogliomas and glioblastomas. The production of IL-6 in these various cells is regulated, either positively or negatively, by a variety of signals including mitogens, antigenic stimulation, lipopolysaccharides, IL-1, TNF, PDGF and viruses. On the basis of its various activities, IL-6 has also been called interferon-β2 (IFN-β2), 26 kDa protein, B-cell stimulatory factor-2 (BSF-2),　hybridoma/plasmacytoma growth factor, hepatocyte stimulating factor, cytotoxic T-cell differentiation factor, and macrophage-granulocyte inducing factor 2A (MGI-2A).The IL-6 cDNA sequence predicts a protein of 212 amino acid residues in length with two potential N-glycosylation sites. The hydrophobic N-terminal 28 amino acid residue signal peptide is cleaved to produce a mature protein of 184 amino acids with four cysteine residues and a predicted molecular mass of 21 kDa. Mouse IL-6 cDNA sequence shows a homology of 42% at the amino acid level when compared with the human sequence. Sequencing of the genomic DNA for IL-6 indicates that the gene for this factor consists of five exons and four introns. On the basis of sequence similarity and gene structural motif similarity, IL-6 can be grouped in a family of cytokines that also includes OSM, G-CSF, LIF, and CNTF. All of these cytokines are predicted to have a four helix bundle structure similar to that found for growth hormone, suggesting that they all evolved from a common ancestral gene.