Rabbit Anti- NOS-2 (iNOS)
2014-04-18 16:40
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资料摘要:
Rabbit Anti- NOS-2 (iNOS)
Catalog Number :HZ77423 Quantity size : 0.2ml (dilute with pH 7.4
0.01 M PBS or antibody diluent )
Background: Nitric oxide (NO) is an inorganic, gaseous free radical that
carries a variety of messages between cells. Vasorelaxation, neurotransmission and
cytotoxicity can all be potentiated through cellular response to NO. NO production is
mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the
oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms,
brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III),
and one inducible isoform (iNOS, type II), have been cloned. Cytokines such as
interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and
lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity
levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity.
Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2).
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