ADAM15 antibody

ADAM15 antibody
Cat.#: 5135-1
Rabbit Monoclonal Antibody
Clone ID: EPR5619
Swiss Prot: Q13444
Mol Weight: 110 (pro-ADAM15) / 90 kDa (mature)
Size: 100ul

Description
ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. ADAM15 contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, it specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that ADAM15 may function in cell-cell adhesion as well as in cellular signaling (1).

Recommended Applications
WB, IHC, IP

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
IP: 1:10 - 100

Species Reactivity
Human

Species cross-reactivity is based on WB analysis.

Products Data 

Specificity
A synthetic peptide corresponding to residues in the extracellular domain in human ADAM15 was used as an immunogen.

Storage Condition and Buffer
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ADAM15 antibody, MDC15 antibody, Disintegrin and metalloproteinase domain-containing protein 15 antibody, Metargidin antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.