爪肿测量仪

爪肿测量仪 仪器简介：

爪肿测量仪计用于测量抗肿药物的效果．爪肿测量仪使用方法简单，将肿胀的大鼠爪放入仪器的水槽中，导致水平面上升，爪肿测量仪测量出水平面上升引起的水压力变化值，该压力变化值对应伸入水中肿胀大鼠爪的体积；

爪肿测量仪  的详细介绍  

产品品牌：意大利UGO
产品型号：37140


爪肿测量仪设计用于风湿关节炎、水肿、药理作用等研究，精确测量啮齿类动物肢体的肿胀情况。自上世纪60年代起，已经有超过1000篇的引文。该仪器是大、小鼠炎症水肿测量的理想工具，其测量分辨率是0.01ml。
 
爪肿测量仪整套仪器包含一个脚踏开关，用于记录读数，从而使得操作人员可以全神贯注于将动物的爪侵没于测量水杯中。液晶屏实时显示实验数据，通过相应软件可方便的将实验数据导入电脑。


爪肿测量仪使用方法简单，将肿胀的大鼠爪放入仪器的水槽中，导致水平面上升，爪肿测量仪测量出水平面上升引起的水压力变化值，该压力变化值对应伸入水中肿胀大鼠爪的体积；对大鼠服用抗肿胀药物，大鼠的爪相应消肿，将消肿的大鼠爪放入水槽中，导致水平面上升，爪肿测量仪测量出水平面上升引起的水压力变化值，该压力变化值对应伸入水中消肿大鼠爪的体积，根据两次水压力变化值即体积的差值评估得出抗肿胀药物的效果。


特征
 
脚踏记录实验数据
超过1000引文
多测量水杯可选

优点
 

免手持操作
   绝大多数应用开在参考文献中查到
  可用于大、小鼠实验

规格参数：

测量水杯直径：1.3 cm (小鼠), 1.8; 2.5 & 3.5 cm (大鼠)
读数分别率：0.01ml
与电脑连接：串行接口或USB接口
软件：包含在标配中

参考文献：

  et alia: “A2A Adenosine Receptors Are Differentially Modulated by Pharmacological Treatments in Rheumatoid Arthritis Patients and Their Stimulation Ameliorates Adjuvant-Induced Arthritis in Rats” PLoS ONE 8(1): e54195, 2013

§ T. Bertaim et alia: “Dose and Administration Schedule Effect of Tiludronate on Joint Damage in the Model of Complete Freund Adjuvant Induced Monoarthritis in Rats” Open Journal of Rheumatology and Autoimmune Diseases 3: 18-25, 2013

§ E. Borbély et alia: “Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse” PLoS ONE 8(4): e61684,2013

 ......

§ R. Korhonen et alia: “Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1” Br. J. Pharmacol. 169 (7):1525-1536, 2013

 § A. Finlay et alia: “Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism” PLoS ONE 8(1): e55255, 2013.....

§ D. Piomelli et alia:” Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism”. Nature NSC, 2010

§ L.H. Santos et alia: "Anti-Inflammatory, antinociceptive and Ulcerogenic Activity of a Zinc-Diclofenac Complex in Rats" Brazil. J. Med. Biol. Res. 37: 1205-1213, 2004

§ D.W. Li et alia: "Antiinflammatory Activity of a α-Hederin methyl Ester from the Alkaline Hydrolysate of the Butanol Fraction of Kalopanax Pictus Bark Extract" Biol. Pharm. Bull. 26 (4): 429-433, 2003

§ A. Rotelli et alia: “Comparative Study of Flavonoids in Experimental Models of Inflammation” Pharmacol. Research 48: 601-606, 2003

§ H. Machelska et alia: "Opioid Control of Inflammatory Pain Regulated by Intercellular Adhesion Molecule-1" J. Neuroscience 22 (13), 5588-5596, 2002

§ W. Binder & J. Walker: "Effect of the Peripherally Selective Κ-Opioid Agonist, Asimadoline, on Adjuvant Arthritis" Br. J. Pharmacol. 124: 647-654, 1998

§F. Vincenzi