Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli derived)
价格： 面议
品牌：派普泰克
供货周期： 两周
货号：AF-120-14E-100ug
规格：100ug
获取电话Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
Manufactured using all Animal-Free reagents.
Source: E.coli
Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein, Erythroid Differentiation Factor (EDF)
AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
This product has been tested against the WHO standard. International Unit information can be found here.
Calculated Molecular Weight: 26 kDa
Accession Number: P08476
Gene ID: 3624
Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
Note:
1mg will be provided as 2x500μg.
crossreactivity:
