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FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.
Source: E.coli
Synonyms: Fibroblast Growth Factor-8, FGF-8b, AIGF, HBGF-8
AA Sequence: MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is 2.0-4.0 ng/ml
Recombinant Human/Murine FGF-8b Biological Activity Graph
Calculated Molecular Weight: 22.5 kDa
Accession Number: P55075
Gene ID: 2253
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Note:
1mg will be provided as 2x500μg
Cross Reactivity Cited in References:
Chicken, Hamster, Human, Mouse, Rabbit, Rat
