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VEGF-D, a member of the VEGF/PDGF family of structurally-related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surface-associated, non-covalent, disulfide-linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant Human VEGF-D is a 26.2 kDa, non-disulfide linked, homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation, the protein migrates as a 20.0-22.0 kDa band by SDS-PAGE analysis under non-reducing conditions.
Source: HEK293 cells
Synonyms: Vascular Endothelial Growth Factor-D, FIGF
AA Sequence (monomer): FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Measured by its ability to bind recombinant human VEGFR3/Flt-4 Fc in a functional ELISA.
Recombinant Human VEGF-D Biological Activity Graph
Calculated Molecular Weight: 26.2 kDa
Accession Number: O43915
Gene ID: 2277
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Cross Reactivity Cited in References:
Mouse
