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KGF (FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF (FGF-7) is a mitogen factor specific for epithelial cells and keratinocytes. KGF (FGF-7) signals through FGFR 2b. KGF (FGF-7) plays a role in kidney and lung development, as well as in angiogenesis and wound healing. Recombinant Human KGF (FGF-7) is an 18.9 kDa protein consisting of 163 amino acid residues.
Source: E.coli
Synonyms: Keratinocyte Growth Factor, Fibroblast Growth Factor-7, HBGF-7
AA Sequence: CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by a cell proliferation assay using 4MBr-5 cells. The expected ED50 for this effect is 0.1-15 ng/ml.
This product has been tested against the WHO standard. International Unit information can be found here.
Recombinant Human KGF (FGF-7) WHO Comparison Graph Recombinant Human KGF (FGF-7) Biological Activity Graph
Calculated Molecular Weight: 18.9 kDa
Accession Number: P21781
Gene ID: 2252
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Cross Reactivity Cited in References:
Human, Leech, Mouse, Rat
