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FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.
Qualified for stem cell use.
Source: E.coli
Synonyms: Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin
AA Sequence: AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
This product has been tested against the WHO standard. International Unit information can be found here.
Recombinant Human FGF-basic (154 a.a.) Biological Activity Graph
Calculated Molecular Weight: 17.2 kDa
Accession Number: P09038
Gene ID: 2247
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
crossreactivity:
Alpaca, Bacteria, Chicken, Cow, Dog, Frog, Guinea Pig, Hamster, Horse, Human, Human + Hamster, Human + Mouse, Human + Rat, Human + Virus, Monkey, Mouse, Mouse + Chicken, Mouse + Pig, Mouse + Rat, Pig, Rabbit, Rat, Rat + Chicken, Sheep
