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- 保存条件:-20℃
2,3-DCPE盐酸盐
2,3-DCPE hydrochloride
产品规格: 5mg
CAS: 418788-90-6
保存条件: Store at -20℃
产品介绍：
CAS号：418788-90-6
分子式：C11H15Cl2NO2.HCl
分子量：300.61
纯度：99%(HPLC)
熔点：139-142℃
沸点：429.8℃ at 760 mmHg
溶解性：Soluble in water (>25 mg/ml), ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS (pH7.2) (~10 mg/ml).
产品描述：2,3 DCPE displays anticancer agent properties and induces ERK activation. Causes apoptosis in many tumor cell lines and is known to specifically cleave caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells, but not in human fibroblasts. Shown to reduce the protein level of Bcl-XL. Triggered cell death in OAW42-R ovarian carcinoma cells with inhibition of Bcl-2 expression and increased cytotoxic effect of cisplatin in OAW42-R resistant cells. 2,3-DCPE reported to induce S-phase arrest and upregulate p21.
IC50：LoVo colon cancer cell line: IC50 = 0.89 μM (human); normal fibroblasts: IC50 = 12.6 μM (human)
用途：A compound that induces both upregulation and S-phase arrest in p21.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
