别称
KIAA0268, TANGO, TANGO1
宿主
Rabbit
适应种属
Human, Mouse, Rat
亚型
IgG
验证应用
ELISA, IP, WB
产品信息
产品名称
anti- MIA3 antibody
货号
QSab05174
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
宿主
Rabbit
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
背景介绍
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII(COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum(PubMed:27138255).
免疫原信息
免疫原
melanoma inhibitory activity family, member 3
别称
KIAA0268, TANGO, TANGO1
分子量
250 kDa
应用
验证应用
ELISA, IP, WB
建议稀释比例
WB: 1:500-1:2000; IP: 1:200-1:1000
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