获取电话兔抗AR多克隆抗体
中文名称：兔抗AR多克隆抗体
英文名称： Anti-AR rabbit polyclonal antibody
别 名： KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
储 存： 冷冻（-20℃）
抗 原： AR
宿 主： Rabbit
反应种属： Human, Mouse, Rat
相关类别： 一抗
标记物： Unconjugate
克隆类型： rabbit polyclonal
技术规格：兔抗AR多克隆抗体
IHC Recommend dilution: | 25-100 |
IHC positive control: | Human colorectal cancer and human liver cancer |
ELISA Recommended dilution: | 5000-10000 |
SwissProt: | P10275 |
Synonyms: | KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA |
Full name: | androgen receptor |
Immunogen: | Synthetic peptide of human AR |
Name of antibody: | AR |
Applications: | ELISA, IHC |
Background: | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. |
