获取电话兔抗LINGO1多克隆抗体
中文名称： 兔抗LINGO1多克隆抗体
英文名称： Anti-LINGO1 rabbit polyclonal antibody
别 名： LERN1; LRRN6A; UNQ201
相关类别： 一抗
储 存： 冷冻（-20℃）
宿 主： Rabbit
抗 原： LINGO1
反应种属： Human, Mouse
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格： 兔抗LINGO1多克隆抗体
Background: | Lingo-1 is a 614-amino acid protein that plays an important role in the negative regulation of myelination by oligodendrocytes in the central nervous system (CNS). Lingo-1 is a nervous system-specific transmembrane protein that interacts with NgR1 and p75 to make up a receptor complex that binds to Nogo, a protein that inhibits axonal regeneration. Reduction of Lingo-1 activity downregulates RhoA (a protein related to cytoskeleton regulation) activity, promotes oligodendrocyte differentiation, and increases axonal myelination in neuronal tissues. Conversely, overexpression of Lingo-1 activates RhoA and inhibits oligodendrocyte differentiation and myelination. Lingo-1 up-regulation may be a characteristic of activity-induced neural plasticity responses. Lingo-1 may be a critical deterrent of myelin and nerve fiber repair in multiple sclerosis, an inflammatory disease that causes gradual destruction of myelin in the CNS. |
Applications: | ELISA, IHC |
Name of antibody: | LINGO1 |
Immunogen: | Synthetic peptide of human LINGO1 |
Full name: | leucine rich repeat and Ig domain containing 1 |
Synonyms: | LERN1; LRRN6A; UNQ201 |
SwissProt: | Q96FE5 |
ELISA Recommended dilution: | 5000-10000 |
IHC positive control: | Human cervical cancer |
IHC Recommend dilution: | 10-50 |
