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UPCISCC090 人舌头鳞癌细胞 QCH766
一周
3500￥
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KNS62 人肺支气管鳞状细胞癌 QCH767
一周
3500￥
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HCC95 人肺腺癌细胞 QCH768
一周
3500￥
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HARA 人肺腺癌细胞 QCH769
一周
3500￥
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EPLC272H 人肺腺癌细胞 QCH770
一周
4000￥
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NCI-H810 人非小细胞肺癌细胞 QCH771
一周
5000￥
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HBL-1 人弥漫性大B细胞淋巴瘤 QCH772
一周
1800￥
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FTC238 人滤泡状甲状腺癌细胞，肺转移 XY-H773
一周
3500￥
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SNU-719 人胃癌细胞 QCH774
一周
3500￥
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BT549+GFP+LUC 人乳腺癌细胞 QCH766GL
钦诚生物 | 一周
4500￥
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抑制剂描述： 产品名称：6-Thioguanine 产品别名：见爱必信官网 英文别名：6-Thioguanine 靶点：DNA Methyltransferase CAS：154-42-7 纯度：≥98% 外观：见爱必信官网 保存方法：Store at -20° C 描述： 6-Thioguanine is a chemotherapy drug that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein. 溶解性：DMSO : 14 mg/mL (83.7 mM) 体外研究： Thioguanine incorporation alters the DNA cleavage induced by topoisomerase II in the presence and absence of etoposide. 6-Thioguanine alters the structure and lowers the thermal stability of duplex DNA, but duplex DNA can be formed in the presence of 6SG. 6-Thioguanine induced apopotosis is similarly observed in both mismatch repair-proficient and -deficient HCT116 and HeLa cells. Thioguanine integrates into DNA and unlike the canonical DNA bases, it is a strong UVA chromophore with an absorbance maximum at 342 nm. 6-Thioguanine is a photosensitizer and a source of reactive oxygen species. In canine lymphoma cells, Thioguanine significantly decreases DNMT1 protein and global DNA methylation. 体内研究：Thioguanine is as efficient as a PARP inhibitor in selectively killing BRCA2-defective tumors in a xenograft model. 6-Thioguanine efficiently kills such BRCA1-defective PARP inhibitor-resistant tumors. 6-Thioguanine could kill cells and tumors that have gained resistance to PARP inhibitors or cisplatin through genetic reversion of the BRCA2 gene.
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